SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2lb5 SENSOR HISTIDINE
KINASE
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 8 LEU A 181
LEU A 166
PRO A 173
GLY A  47
 None
 0.98A 2po5A-2lb5A:
undetectable		 2po5A-2lb5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2lb5 SENSOR HISTIDINE
KINASE
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 6 VAL A  53
LEU A 156
ILE A 195
VAL A  42
 None
 0.91A 4a9kA-2lb5A:
0.0		 4a9kA-2lb5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2lb5 SENSOR HISTIDINE
KINASE
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		3 / 3 VAL A  65
THR A  63
ARG A  55
 None
 0.67A 5b2sB-2lb5A:
undetectable		 5b2sB-2lb5A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2lb5 SENSOR HISTIDINE
KINASE
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		3 / 3 VAL A  65
THR A  63
ARG A  55
 None
 0.68A 5b2tB-2lb5A:
undetectable		 5b2tB-2lb5A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2lb5 SENSOR HISTIDINE
KINASE
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 5 GLY A  71
ASP A  49
ARG A  69
ARG A  73
 None
 1.40A 6dwdB-2lb5A:
undetectable
6dwdD-2lb5A:
undetectable		 6dwdB-2lb5A:
15.43
6dwdD-2lb5A:
15.43