SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 6 PHE A   2
GLU A  86
GLY A  88
THR A 100
 None
 0.93A 1icuA-2lbaA:
undetectable
1icuB-2lbaA:
undetectable		 1icuA-2lbaA:
22.37
1icuB-2lbaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 6 THR A 100
PHE A   2
GLU A  86
GLY A  88
 None
 0.95A 1kqbA-2lbaA:
undetectable
1kqbB-2lbaA:
undetectable		 1kqbA-2lbaA:
20.63
1kqbB-2lbaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 6 THR A 100
PHE A   2
GLU A  86
GLY A  88
 None
 0.93A 1kqbC-2lbaA:
undetectable
1kqbD-2lbaA:
undetectable		 1kqbC-2lbaA:
20.63
1kqbD-2lbaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 6 PHE A   2
GLU A  86
GLY A  88
THR A 100
 None
 1.01A 1kqbC-2lbaA:
undetectable
1kqbD-2lbaA:
undetectable		 1kqbC-2lbaA:
20.63
1kqbD-2lbaA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 ASN A  61
PHE A  63
VAL A  83
PHE A  94
HIS A  99
 CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.9A)
CHO  A 201 (-3.0A)
 0.96A 2ft9A-2lbaA:
18.8		 2ft9A-2lbaA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 PHE A  17
ASN A  61
PHE A  63
VAL A  83
HIS A  99
 CHO  A 200 ( 4.3A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-3.0A)
 0.72A 2ft9A-2lbaA:
18.8		 2ft9A-2lbaA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 ILE A  21
THR A  73
MET A  74
HIS A  99
ARG A 121
 CHO  A 201 ( 4.3A)
CHO  A 201 (-2.8A)
CHO  A 200 (-2.6A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 1.19A 2qo4A-2lbaA:
20.3		 2qo4A-2lbaA:
45.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 TYR A  14
ILE A  21
THR A  73
HIS A  99
ARG A 121
 CHO  A 200 ( 3.8A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 0.74A 2qo4A-2lbaA:
20.3		 2qo4A-2lbaA:
45.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		6 / 12 TYR A  14
ILE A  21
LEU A  23
THR A  73
HIS A  99
ARG A 121
 CHO  A 200 ( 3.8A)
CHO  A 201 ( 4.3A)
CHO  A 200 (-3.9A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 0.75A 2qo6A-2lbaA:
20.3		 2qo6A-2lbaA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 5 PHE A  94
SER A 114
PHE A  63
ILE A  21
 CHO  A 201 (-2.9A)
None
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.3A)
 1.33A 2v0mD-2lbaA:
undetectable		 2v0mD-2lbaA:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		8 / 12 TRP A  49
GLN A  51
ASN A  61
PHE A  63
MET A  71
THR A  73
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 1.05A 3elzA-2lbaA:
19.5		 3elzA-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		6 / 11 TRP A  49
GLN A  51
MET A  71
THR A  73
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 0.97A 3elzB-2lbaA:
19.0		 3elzB-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		7 / 12 TRP A  49
GLN A  51
ASN A  61
THR A  73
PHE A  79
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 1.02A 3elzC-2lbaA:
17.6		 3elzC-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 MET A  71
THR A  73
PHE A  79
VAL A  83
THR A 100
 CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
None
 1.28A 3em0A-2lbaA:
19.2		 3em0A-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		8 / 12 TRP A  49
GLN A  51
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
TYR A  97
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.6A)
 0.90A 3em0A-2lbaA:
19.2		 3em0A-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 5 ILE A  21
THR A  73
PHE A  79
PHE A  94
TYR A  97
 CHO  A 201 ( 4.3A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 (-2.9A)
CHO  A 201 (-2.6A)
 1.15A 3em0A-2lbaA:
19.2		 3em0A-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		7 / 12 PHE A  17
ILE A  21
MET A  71
THR A  73
PHE A  79
VAL A  83
THR A 100
 CHO  A 200 ( 4.3A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
None
 1.42A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		8 / 12 PHE A  17
ILE A  21
TRP A  49
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
 CHO  A 200 ( 4.3A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.9A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
 0.79A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		7 / 12 TRP A  49
GLN A  51
ASN A  61
MET A  71
THR A  73
PHE A  79
VAL A  83
 CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-2.4A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.5A)
CHO  A 201 ( 4.0A)
 0.95A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 7 ILE A  21
PHE A  79
PHE A  94
TYR A  97
 CHO  A 201 ( 4.3A)
CHO  A 201 (-3.5A)
CHO  A 201 (-2.9A)
CHO  A 201 (-2.6A)
 0.86A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 7 LYS A  89
THR A 100
GLU A 102
VAL A 109
 None
 0.59A 3em0B-2lbaA:
19.7		 3em0B-2lbaA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 5 GLY A  88
LYS A  89
GLU A 102
GLY A  87
 None
 0.86A 3onnA-2lbaA:
undetectable		 3onnA-2lbaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2lba BABP PROTEIN
(Gallus
gallus) 		4 / 8 GLY A  87
ILE A  90
GLU A 110
GLU A 102
 None
CHO  A 201 ( 4.2A)
CHO  A 201 (-3.7A)
None
 0.85A 4mwzB-2lbaA:
undetectable		 4mwzB-2lbaA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 2lba BABP PROTEIN
(Gallus
gallus) 		5 / 12 TYR A  14
TRP A  49
GLN A  51
GLU A 110
SER A 112
 CHO  A 200 ( 3.8A)
CHO  A 201 (-2.9A)
CHO  A 201 ( 3.4A)
CHO  A 201 (-3.7A)
CHO  A 200 ( 4.5A)
 0.91A 5l8oB-2lbaA:
20.0		 5l8oB-2lbaA:
60.61