SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B 108
ILE B 155
LEU A  14
ILE A  15
 None
 0.93A 2azxA-2lbfB:
undetectable		 2azxA-2lbfB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 12 VAL A  21
THR A  22
ASP A  26
ALA A  30
ILE B 126
 None
 1.04A 3a35A-2lbfA:
undetectable		 3a35A-2lbfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 12 VAL A  21
THR A  22
ASP A  26
ALA A  30
ILE B 126
 None
 1.07A 3a35B-2lbfA:
undetectable		 3a35B-2lbfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 12 VAL A  21
THR A  22
ASP A  26
ALA A  30
ILE B 126
 None
 1.07A 3a3bA-2lbfA:
undetectable		 3a3bA-2lbfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 12 LEU B 112
GLY A  36
ILE B 151
GLY B 114
GLY B 113
 None
 0.94A 3axzA-2lbfB:
undetectable		 3axzA-2lbfB:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 12 MET B 101
ALA B 163
LEU B 146
LEU B 108
ILE B 123
 None
 1.13A 3fl9B-2lbfB:
undetectable		 3fl9B-2lbfB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 10 MET B 101
ALA B 163
LEU B 146
LEU B 108
ILE B 123
 None
 0.93A 3fl9E-2lbfB:
undetectable		 3fl9E-2lbfB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.13A 3n62A-2lbfB:
undetectable		 3n62A-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.03A 3n66B-2lbfB:
undetectable		 3n66B-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 8 SER B 117
ASN B 147
ILE B 143
ASN B 115
ASP B 122
 None
 1.48A 4d33A-2lbfB:
undetectable		 4d33A-2lbfB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 7 SER B 117
ASN B 147
ILE B 143
ASN B 115
ASP B 122
 None
 1.49A 4d33B-2lbfB:
undetectable		 4d33B-2lbfB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 7 SER B 117
ASN B 147
ILE B 143
ASN B 115
ASP B 122
 None
 1.49A 4d39B-2lbfB:
undetectable		 4d39B-2lbfB:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
(Homo
sapiens) 		4 / 7 ALA A  50
ALA A  13
ILE A  10
ILE A  56
 None
 0.63A 4eatA-2lbfA:
undetectable		 4eatA-2lbfA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 7 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.04A 4kcnB-2lbfB:
undetectable		 4kcnB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		5 / 9 ALA B 105
ILE B 155
VAL B 154
ALA B 111
ILE B 151
 None
 1.04A 4lbgB-2lbfB:
undetectable		 4lbgB-2lbfB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.05A 5vunA-2lbfB:
undetectable		 5vunA-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 0.97A 5vunB-2lbfB:
undetectable		 5vunB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.00A 5vuoB-2lbfB:
undetectable		 5vuoB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 112
GLY A  36
ILE B 151
GLY B 114
GLY B 113
 None
 0.98A 5wyqB-2lbfB:
undetectable		 5wyqB-2lbfB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 8 SER B 117
ASN B 147
ASN B 115
ASP B 122
 None
 1.02A 6auuB-2lbfB:
undetectable		 6auuB-2lbfB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 7 PHE A  47
ILE A  28
LEU A  31
ILE B 159
 None
 0.63A 6b5vA-2lbfA:
undetectable
6b5vC-2lbfA:
undetectable		 6b5vA-2lbfA:
23.81
6b5vC-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 7 PHE A  47
ILE A  28
LEU A  31
ILE B 159
 None
 0.63A 6b5vA-2lbfA:
undetectable
6b5vB-2lbfA:
undetectable		 6b5vA-2lbfA:
23.81
6b5vB-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 7 PHE A  47
ILE A  28
LEU A  31
ILE B 159
 None
 0.63A 6b5vC-2lbfA:
undetectable
6b5vD-2lbfA:
undetectable		 6b5vC-2lbfA:
23.81
6b5vD-2lbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2
(Homo
sapiens) 		4 / 7 PHE A  47
ILE A  28
LEU A  31
ILE B 159
 None
 0.63A 6b5vB-2lbfA:
undetectable
6b5vD-2lbfA:
undetectable		 6b5vB-2lbfA:
23.81
6b5vD-2lbfA:
23.81