SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lbp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A 100
ASP A  51
HIS A  76
ALA A  58
 None
 0.92A 1gxsA-2lbpA:
3.3
1gxsB-2lbpA:
undetectable		 1gxsA-2lbpA:
22.74
1gxsB-2lbpA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 196
VAL A 333
VAL A 158
ILE A 132
 None
 0.99A 1p7rA-2lbpA:
undetectable		 1p7rA-2lbpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 9 VAL A   7
VAL A   8
GLY A  75
PRO A  99
GLY A  25
 None
 1.40A 3bjwG-2lbpA:
undetectable		 3bjwG-2lbpA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 SER A 183
GLN A 212
PHE A 182
 None
 0.71A 3g4lC-2lbpA:
undetectable		 3g4lC-2lbpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 GLY A  25
ILE A 315
VAL A 314
 None
 0.46A 3nv6A-2lbpA:
undetectable		 3nv6A-2lbpA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 224
GLN A 124
PHE A 222
MET A 244
GLU A 226
 None
 1.27A 3t7sB-2lbpA:
undetectable		 3t7sB-2lbpA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 224
GLN A 124
PHE A 222
MET A 244
GLU A 226
 None
 1.26A 3t7sD-2lbpA:
3.9		 3t7sD-2lbpA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 318
ALA A 290
MET A 115
THR A 117
 None
 1.06A 3vasB-2lbpA:
undetectable		 3vasB-2lbpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 TYR A 202
GLY A 224
GLY A 227
TYR A 203
ALA A 128
 None
 0.96A 3vywB-2lbpA:
undetectable		 3vywB-2lbpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A 297
SER A 296
GLY A 295
ASP A  42
 None
 1.11A 3w9tB-2lbpA:
undetectable		 3w9tB-2lbpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A 297
SER A 296
GLY A 295
ASP A  42
 None
 1.11A 3w9tC-2lbpA:
undetectable		 3w9tC-2lbpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A 297
SER A 296
GLY A 295
ASP A  42
 None
 1.11A 3w9tD-2lbpA:
undetectable		 3w9tD-2lbpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 SER A 122
ASP A 121
THR A 127
THR A 102
 None
 1.08A 4acbC-2lbpA:
2.0		 4acbC-2lbpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.93A 4olbA-2lbpA:
4.8		 4olbA-2lbpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 161
ILE A 132
GLY A 200
PHE A 172
ILE A 143
 None
 1.17A 4qoiA-2lbpA:
4.3
4qoiB-2lbpA:
4.4		 4qoiA-2lbpA:
21.94
4qoiB-2lbpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.82A 4txnA-2lbpA:
4.8		 4txnA-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.80A 4txnB-2lbpA:
4.8		 4txnB-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.81A 4txnC-2lbpA:
3.0		 4txnC-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.79A 4txnD-2lbpA:
4.8		 4txnD-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.78A 4w5nA-2lbpA:
4.3		 4w5nA-2lbpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 SER A  98
GLY A  75
ALA A  16
GLY A   9
 None
 0.88A 5albL-2lbpA:
undetectable		 5albL-2lbpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 MET A  96
LEU A 287
ALA A 283
GLY A   9
HIS A  76
 None
 1.32A 5dx3A-2lbpA:
undetectable		 5dx3A-2lbpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 ILE A 141
ALA A 155
VAL A 158
HIS A 145
 None
 0.82A 5eclD-2lbpA:
undetectable		 5eclD-2lbpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  32
ILE A  39
ASN A  24
TYR A 281
 None
 1.17A 6a93B-2lbpA:
undetectable		 6a93B-2lbpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 VAL A   8
ILE A  65
LEU A  95
LEU A 287
ALA A 283
 None
 0.97A 6ajiA-2lbpA:
undetectable		 6ajiA-2lbpA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2lbp LEUCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 185
SER A 183
PHE A 182
 None
 0.62A 6fgcA-2lbpA:
4.3		 6fgcA-2lbpA:
22.30