SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	LEU A 110 GLY A 114 SER A 121 ILE A 81 GLY A 111	None	0.99A	3axzA-2lbwA: undetectable	3axzA-2lbwA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	ASN A 130 GLU A 71 VAL A 76 ILE A 125 ASN A 55	None	1.49A	3jb3A-2lbwA: undetectable	3jb3A-2lbwA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	ASN A 130 GLU A 71 VAL A 123 ILE A 125 ASN A 55	None	1.36A	3jb3A-2lbwA: undetectable	3jb3A-2lbwA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J5J_B_478B401_2 (PROTEASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 10	ASN A 40 ILE A 102 VAL A 43 PRO A 100 VAL A 153	None	1.06A	4j5jB-2lbwA: undetectable	4j5jB-2lbwA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	LEU A 110 GLY A 114 SER A 121 ILE A 81 GLY A 111	None	0.93A	4yvgA-2lbwA: undetectable	4yvgA-2lbwA: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	LEU A 110 GLY A 114 SER A 121 ILE A 81 GLY A 111	None	0.91A	5wyqA-2lbwA: undetectable	5wyqA-2lbwA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	LEU A 110 GLY A 114 SER A 121 ILE A 81 GLY A 111	None	0.95A	5wyqB-2lbwA: undetectable	5wyqB-2lbwA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	2lbw	H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 (Saccharomyces cerevisiae)	5 / 12	LEU A 110 GLY A 114 SER A 121 ILE A 81 GLY A 111	None	0.89A	5zhmB-2lbwA: undetectable	5zhmB-2lbwA: 20.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3AXZ_A_ADNA401_1","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"LEU A 110;GLY A 114;SER A 121;ILE A  81;GLY A 111","None","0.99A","3axzA-2lbwA:undetectable","3axzA-2lbwA:20.47"],["3JB3_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"ASN A 130;GLU A  71;VAL A  76;ILE A 125;ASN A  55","None","1.49A","3jb3A-2lbwA:undetectable","3jb3A-2lbwA:8.30"],["3JB3_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"ASN A 130;GLU A  71;VAL A 123;ILE A 125;ASN A  55","None","1.36A","3jb3A-2lbwA:undetectable","3jb3A-2lbwA:8.30"],["4J5J_B_478B401_2","PROTEASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"ASN A  40;ILE A 102;VAL A  43;PRO A 100;VAL A 153","None","1.06A","4j5jB-2lbwA:undetectable","4j5jB-2lbwA:24.59"],["4YVG_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"LEU A 110;GLY A 114;SER A 121;ILE A  81;GLY A 111","None","0.93A","4yvgA-2lbwA:undetectable","4yvgA-2lbwA:20.47"],["5WYQ_A_SAMA401_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"LEU A 110;GLY A 114;SER A 121;ILE A  81;GLY A 111","None","0.91A","5wyqA-2lbwA:undetectable","5wyqA-2lbwA:20.36"],["5WYQ_B_SAMB301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"LEU A 110;GLY A 114;SER A 121;ILE A  81;GLY A 111","None","0.95A","5wyqB-2lbwA:undetectable","5wyqB-2lbwA:20.36"],["5ZHM_B_SAMB301_1","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","2lbw","H\/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2","Saccharomyces cerevisiae",5,"LEU A 110;GLY A 114;SER A 121;ILE A  81;GLY A 111","None","0.89A","5zhmB-2lbwA:undetectable","5zhmB-2lbwA:20.43"]]