SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 0.94A 1rxcC-2lc0A:
undetectable		 1rxcC-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 0.99A 1rxcD-2lc0A:
undetectable		 1rxcD-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 1.02A 1rxcF-2lc0A:
undetectable		 1rxcF-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 1.03A 1rxcL-2lc0A:
undetectable		 1rxcL-2lc0A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.80A 2nnkA-2lc0A:
undetectable		 2nnkA-2lc0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  63
ILE A  64
ALA A 121
ARG A 120
ALA A  44
 None
 1.04A 3gwsX-2lc0A:
undetectable		 3gwsX-2lc0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.75A 3k4vA-2lc0A:
undetectable		 3k4vA-2lc0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.74A 3k4vD-2lc0A:
undetectable		 3k4vD-2lc0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.71A 3nduD-2lc0A:
undetectable		 3nduD-2lc0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.87A 3pwrA-2lc0A:
undetectable		 3pwrA-2lc0A:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  10
VAL A 125
THR A 100
 None
 0.78A 3tl9A-2lc0A:
undetectable		 3tl9A-2lc0A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 1.02A 4e1vB-2lc0A:
undetectable		 4e1vB-2lc0A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  29
ILE A  31
VAL A  32
PRO A  33
 None
 0.98A 4e1vC-2lc0A:
undetectable		 4e1vC-2lc0A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 130
THR A 131
GLU A  61
THR A 124
 None
 1.13A 5hm8G-2lc0A:
2.4		 5hm8G-2lc0A:
15.51