SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A131_1 (FATTY ACID-BINDING PROTEIN, LIVER)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	5 / 12	PHE A 87 ILE A 177 LEU A 21 THR A 89 HIS A 93	None	1.07A	2jn3A-2lcjA: undetectable	2jn3A-2lcjA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X8O_A_OINA1314_1 (CHOLINE-BINDING PROTEIN F)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	4 / 5	LYS A 41 ASP A 30 ARG A 40 GLU A 31	None	1.23A	2x8oA-2lcjA: 0.0	2x8oA-2lcjA: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_B_ACRB820_1 (ALPHA-AMYLASE, SUSG)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	4 / 7	TYR A 50 LEU A 9 LYS A 18 ASN A 180	None	1.35A	3k8mB-2lcjA: undetectable	3k8mB-2lcjA: 16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQ7_A_LEUA902_0 (LEUCINE--TRNA LIGASE)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	4 / 7	LEU A 149 ASP A 83 GLU A 123 HIS A 145	None	1.25A	4aq7A-2lcjA: undetectable	4aq7A-2lcjA: 14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0Q_A_PX9A201_1 (BETA-LACTOGLOBULIN)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	3 / 3	LYS A 42 ILE A 47 ILE A 12	None	0.63A	4y0qA-2lcjA: undetectable	4y0qA-2lcjA: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I73_A_68PA705_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2lcj	PAB POLC INTEIN (Pyrococcus abyssi)	5 / 9	GLN A 17 GLU A 26 LEU A 167 ILE A 8 PHE A 165	None	1.30A	5i73A-2lcjA: undetectable	5i73A-2lcjA: 15.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JN3_A_JN3A131_1","FATTY ACID-BINDING PROTEIN, LIVER","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",5,"PHE A  87;ILE A 177;LEU A  21;THR A  89;HIS A  93","None","1.07A","2jn3A-2lcjA:undetectable","2jn3A-2lcjA:20.32"],["2X8O_A_OINA1314_1","CHOLINE-BINDING PROTEIN F","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",4,"LYS A  41;ASP A  30;ARG A  40;GLU A  31","None","1.23A","2x8oA-2lcjA:0.0","2x8oA-2lcjA:19.87"],["3K8M_B_ACRB820_1","ALPHA-AMYLASE, SUSG","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",4,"TYR A  50;LEU A   9;LYS A  18;ASN A 180","None","1.35A","3k8mB-2lcjA:undetectable","3k8mB-2lcjA:16.10"],["4AQ7_A_LEUA902_0","LEUCINE--TRNA LIGASE","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",4,"LEU A 149;ASP A  83;GLU A 123;HIS A 145","None","1.25A","4aq7A-2lcjA:undetectable","4aq7A-2lcjA:14.31"],["4Y0Q_A_PX9A201_1","BETA-LACTOGLOBULIN","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",3,"LYS A  42;ILE A  47;ILE A  12","None","0.63A","4y0qA-2lcjA:undetectable","4y0qA-2lcjA:21.95"],["5I73_A_68PA705_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","2lcj","PAB POLC INTEIN","Pyrococcus abyssi",5,"GLN A  17;GLU A  26;LEU A 167;ILE A   8;PHE A 165","None","1.30A","5i73A-2lcjA:undetectable","5i73A-2lcjA:15.79"]]