SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2lct PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 5 ALA A 723
ALA A 734
TYR A 727
GLN A 697
 None
 1.09A 1xl6A-2lctA:
undetectable
1xl6B-2lctA:
undetectable		 1xl6A-2lctA:
15.12
1xl6B-2lctA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2lct PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 GLU A 714
ILE A 718
SER A 708
HIS A 717
ARG A 696
 None
 1.45A 3bwyA-2lctA:
undetectable		 3bwyA-2lctA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2lct PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 GLU A 714
ILE A 718
SER A 708
HIS A 717
ARG A 696
 None
 1.46A 5lsaA-2lctA:
undetectable		 5lsaA-2lctA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2lct PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 6 THR A 759
ASP A 758
LEU A 750
ASP A 752
 None
 1.12A 5tdzA-2lctA:
undetectable		 5tdzA-2lctA:
13.61