SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ld7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 12 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.33A 1q23B-2ld7B:
undetectable		 1q23B-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.31A 1q23E-2ld7B:
undetectable		 1q23E-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 THR B 463
PHE B 468
LEU B 509
VAL B 505
PHE B 484
 None
 1.39A 1q23E-2ld7B:
undetectable		 1q23E-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 11 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.32A 1q23F-2ld7B:
undetectable		 1q23F-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 11 THR B 463
PHE B 468
LEU B 509
VAL B 505
PHE B 484
 None
 1.43A 1q23I-2ld7B:
undetectable		 1q23I-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.33A 1q23K-2ld7B:
undetectable		 1q23K-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 THR B 463
PHE B 468
LEU B 509
VAL B 505
PHE B 484
 None
 1.45A 1q23K-2ld7B:
undetectable		 1q23K-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus;
Mus
musculus) 		4 / 5 TYR A 161
ILE B 490
LEU A 153
LEU A 150
 None
 1.02A 2zb7A-2ld7A:
undetectable		 2zb7A-2ld7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		4 / 6 PHE A 200
VAL B 461
THR B 463
PHE B 522
 None
 1.11A 3ltwA-2ld7A:
undetectable		 3ltwA-2ld7A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 12 PHE B 516
PHE B 508
LEU A 150
GLN A 152
PHE A 186
 None
 1.32A 3tbgA-2ld7B:
undetectable		 3tbgA-2ld7B:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 12 PHE B 516
PHE B 508
LEU A 150
GLN A 152
PHE A 186
 None
 1.30A 3tbgC-2ld7B:
undetectable		 3tbgC-2ld7B:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		4 / 7 VAL A 182
LEU A 150
LEU A 153
ILE B 490
 None
 0.94A 3u5kB-2ld7A:
undetectable		 3u5kB-2ld7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 12 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.27A 3u9fJ-2ld7B:
undetectable
3u9fK-2ld7B:
undetectable		 3u9fJ-2ld7B:
19.23
3u9fK-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 10 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.32A 3u9fR-2ld7B:
undetectable		 3u9fR-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		4 / 5 VAL A 182
LEU A 150
LEU A 153
ILE B 490
 None
 0.94A 4a9jA-2ld7A:
undetectable		 4a9jA-2ld7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		5 / 12 ILE A 189
PHE A 186
LEU A 153
LEU B 504
ILE B 490
 None
 1.01A 4m2xA-2ld7A:
undetectable		 4m2xA-2ld7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A
(Mus
musculus) 		4 / 8 VAL A 182
LEU A 150
LEU A 153
ILE B 490
 None
 0.83A 5y1yA-2ld7A:
undetectable		 5y1yA-2ld7A:
19.84