SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ldx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 9 VAL A  25
GLY A  26
ASP A  51
ALA A  95
ILE A 115
 None
 0.65A 1cetA-2ldxA:
36.9		 1cetA-2ldxA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 9 VAL A  25
GLY A  26
ASP A  51
TYR A  82
ALA A  95
 None
 0.57A 1cetA-2ldxA:
36.9		 1cetA-2ldxA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 8 ALA A  35
LEU A  49
LEU A  64
LYS A  56
 None
 0.74A 1e7cA-2ldxA:
undetectable		 1e7cA-2ldxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 8 ALA A  33
THR A 256
ILE A 251
SER A  37
 None
 0.73A 1gtnP-2ldxA:
undetectable
1gtnQ-2ldxA:
undetectable		 1gtnP-2ldxA:
14.69
1gtnQ-2ldxA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 12 THR A 300
ILE A 299
VAL A 154
CYH A 292
LEU A 258
 None
 1.25A 1wsvB-2ldxA:
undetectable		 1wsvB-2ldxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 6 SER A  85
ALA A  86
SER A 127
THR A  23
 None
 1.21A 1yvpB-2ldxA:
undetectable		 1yvpB-2ldxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 12 LEU A  47
GLY A  42
ILE A 262
VAL A  24
ILE A  22
 None
 0.83A 3k4vA-2ldxA:
undetectable		 3k4vA-2ldxA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 8 SER A 196
SER A 289
LEU A 288
ASP A 140
 None
 0.73A 3lsfH-2ldxA:
undetectable		 3lsfH-2ldxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 11 ALA A  52
ASN A 112
GLY A  96
ALA A  95
VAL A 123
 None
 1.21A 3rukD-2ldxA:
undetectable		 3rukD-2ldxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 6 LYS A 316
ILE A 282
VAL A 276
LEU A 288
 None
 1.11A 4em2A-2ldxA:
undetectable		 4em2A-2ldxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 VAL A 305
MET A 307
GLU A 311
LEU A 189
 None
 1.40A 4hojA-2ldxA:
undetectable		 4hojA-2ldxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 8 PRO A 271
SER A 289
VAL A 272
GLY A 186
 None
 1.01A 4mk4A-2ldxA:
3.8		 4mk4A-2ldxA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 9 ASP A  51
TYR A  82
ALA A  95
ILE A 115
ILE A 119
 None
 0.90A 4oknB-2ldxA:
44.4		 4oknB-2ldxA:
71.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 12 ILE A 199
VAL A 303
VAL A 269
GLY A 159
THR A 143
 None
 1.08A 5igiA-2ldxA:
undetectable		 5igiA-2ldxA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 12 ILE A 199
VAL A 303
VAL A 269
GLY A 159
THR A 143
 None
 1.10A 5igjA-2ldxA:
undetectable		 5igjA-2ldxA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		6 / 12 GLY A 295
LEU A 266
VAL A 272
THR A 273
ALA A 259
LEU A 258
 None
 1.22A 5kpcA-2ldxA:
3.4		 5kpcA-2ldxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 12 ASP A 140
LEU A 241
SER A 196
ARG A  98
LEU A 164
 None
 1.21A 5ogcB-2ldxA:
5.7		 5ogcB-2ldxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 HIS A 230
LEU A 164
CYH A 162
ASP A 194
 None
 1.26A 5vcvA-2ldxA:
undetectable		 5vcvA-2ldxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 LEU A 315
LYS A 316
ALA A 319
LEU A 322
 None
 0.60A 5vkqA-2ldxA:
undetectable
5vkqD-2ldxA:
undetectable		 5vkqA-2ldxA:
11.79
5vkqD-2ldxA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 LEU A 315
LYS A 316
ALA A 319
LEU A 322
 None
 0.59A 5vkqA-2ldxA:
undetectable
5vkqB-2ldxA:
undetectable		 5vkqA-2ldxA:
11.79
5vkqB-2ldxA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 LEU A 315
LYS A 316
ALA A 319
LEU A 322
 None
 0.58A 5vkqB-2ldxA:
undetectable
5vkqC-2ldxA:
undetectable		 5vkqB-2ldxA:
11.79
5vkqC-2ldxA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 5 LEU A 315
LYS A 316
ALA A 319
LEU A 322
 None
 0.59A 5vkqC-2ldxA:
undetectable
5vkqD-2ldxA:
undetectable		 5vkqC-2ldxA:
11.79
5vkqD-2ldxA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		5 / 10 VAL A  30
GLY A  31
LEU A 164
ILE A 133
THR A  94
 None
 0.90A 5vm8B-2ldxA:
2.7		 5vm8B-2ldxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		4 / 8 ASP A 107
HIS A 192
ARG A 105
ASP A 194
 None
 1.20A 6mn4C-2ldxA:
undetectable		 6mn4C-2ldxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ldx APO-LACTATE
DEHYDROGENASE
(Mus
musculus) 		3 / 3 ASP A 242
LEU A 241
ARG A 168
 None
 0.74A 7dfrA-2ldxA:
undetectable		 7dfrA-2ldxA:
18.51