SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2le1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 5 LEU A  93
VAL A  95
CYH A 103
ALA A  12
 None
 1.19A 1mz9D-2le1A:
undetectable		 1mz9D-2le1A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 4 LEU A  93
VAL A  95
CYH A 103
ALA A  12
 None
 1.23A 1mz9E-2le1A:
undetectable		 1mz9E-2le1A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		3 / 3 ARG A  68
VAL A 105
GLY A 133
 None
 0.43A 2avvE-2le1A:
undetectable		 2avvE-2le1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 5 ILE A 125
TYR A  77
ARG A  90
MET A  79
 None
 1.30A 3abkN-2le1A:
undetectable
3abkW-2le1A:
undetectable		 3abkN-2le1A:
12.50
3abkW-2le1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 6 PHE A  53
VAL A 129
ARG A  51
PRO A  37
 None
 1.36A 3n6dA-2le1A:
0.0
3n6dB-2le1A:
0.0		 3n6dA-2le1A:
16.94
3n6dB-2le1A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 6 GLY A 128
GLN A  33
ILE A 125
VAL A 124
 None
 1.09A 4e1vF-2le1A:
undetectable		 4e1vF-2le1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		3 / 3 TYR A  77
PHE A  53
ARG A  51
 None
 1.15A 4g19D-2le1A:
undetectable		 4g19D-2le1A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 7 PHE A 111
HIS A  89
TYR A  77
PHE A 130
 None
 1.05A 4o7gA-2le1A:
undetectable
4o7gB-2le1A:
undetectable		 4o7gA-2le1A:
19.57
4o7gB-2le1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 6 PHE A 111
HIS A  89
TYR A  77
PHE A 130
 None
 1.15A 4o7gB-2le1A:
undetectable		 4o7gB-2le1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		3 / 3 TRP A  18
GLU A  70
ASP A  23
 None
 0.83A 5gqbA-2le1A:
undetectable		 5gqbA-2le1A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2le1 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 8 TRP A  18
GLU A  70
ASP A  23
ARG A  29
 None
 1.00A 5gqbA-2le1A:
undetectable		 5gqbA-2le1A:
13.92