SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2le9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Homo
sapiens) 		4 / 8 LYS A  43
LEU A  48
LEU A  50
SER A  53
 None
 0.97A 1dvtA-2le9A:
undetectable
1dvtB-2le9A:
undetectable		 1dvtA-2le9A:
16.67
1dvtB-2le9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Homo
sapiens) 		4 / 6 LYS A  43
LEU A  48
LEU A  50
SER A  53
 None
 0.89A 1tz8C-2le9A:
1.1
1tz8D-2le9A:
undetectable		 1tz8C-2le9A:
18.46
1tz8D-2le9A:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2le9 PROTEIN S100-A13
(Homo
sapiens) 		5 / 7 VAL B  17
THR B  18
THR B  22
ARG B  25
LYS B  30
 None
 1.32A 2kotA-2le9B:
11.5		 2kotA-2le9B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
PROTEIN S100-A13
(Homo
sapiens) 		4 / 8 ARG B  29
VAL A  46
LEU A  48
PRO A  49
 None
 0.99A 3jq7C-2le9B:
undetectable		 3jq7C-2le9B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Homo
sapiens) 		3 / 3 GLU A  60
ASP A  65
PRO A  63
 None
 0.76A 6berA-2le9A:
undetectable		 6berA-2le9A:
14.89