SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2leh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2leh SURVIVAL OF MOTOR
NEURON
PROTEIN-INTERACTING
PROTEIN 1
SURVIVAL MOTOR
NEURON PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL A 183
SER A 184
LEU B  39
HIS A 120
 None
 1.28A 2f8dA-2lehA:
undetectable		 2f8dA-2lehA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2leh SURVIVAL OF MOTOR
NEURON
PROTEIN-INTERACTING
PROTEIN 1
SURVIVAL MOTOR
NEURON PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A 219
GLN A 109
VAL A 113
ILE B  40
ASP B  44
 None
 1.17A 4uuuA-2lehA:
undetectable
4uuuB-2lehA:
undetectable		 4uuuA-2lehA:
17.53
4uuuB-2lehA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2leh SURVIVAL OF MOTOR
NEURON
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 ARG A 240
PHE A 202
ASP A 206
LEU A 149
 None
 1.37A 5uhdC-2lehA:
undetectable		 5uhdC-2lehA:
9.16