SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2leq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD6_0
(GRAMICIDIN D)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		4 / 4 TRP A  21
TRP A  43
ALA A  23
VAL A  25
 None
 1.40A 1w5uC-2leqA:
undetectable
1w5uD-2leqA:
undetectable		 1w5uC-2leqA:
8.20
1w5uD-2leqA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC6_0
(GRAMICIDIN D)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		4 / 4 ALA A  23
VAL A  25
TRP A  21
TRP A  43
 None
 1.38A 2izqC-2leqA:
undetectable
2izqD-2leqA:
undetectable		 2izqC-2leqA:
8.20
2izqD-2leqA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		4 / 7 ASP A  62
PHE A  80
TYR A  60
TRP A  55
 None
 1.44A 2q6kA-2leqA:
undetectable		 2q6kA-2leqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		3 / 3 ARG A  72
GLU A  18
SER A  41
 None
 0.91A 2xctD-2leqA:
undetectable		 2xctD-2leqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		4 / 7 VAL A  20
LYS A  19
LYS A 137
GLU A 141
 None
 0.93A 3hs4A-2leqA:
undetectable		 3hs4A-2leqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		3 / 3 LYS A  86
PRO A  87
LEU A  89
 None
 0.71A 3tpxE-2leqA:
undetectable		 3tpxE-2leqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2leq UNCHARACTERIZED
PROTEIN
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 103
GLY A 106
ASN A  14
ALA A  23
LEU A 136
 None
 1.06A 3vywC-2leqA:
undetectable		 3vywC-2leqA:
20.13