SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 12 LEU A 394
MET A 390
ILE A 354
PHE A 364
ILE A 403
 None
 1.46A 1osvB-2lf8A:
0.0		 1osvB-2lf8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		4 / 6 GLY A 371
TYR A 340
ASP A 368
ASN A 370
 None
 1.13A 2g72A-2lf8A:
undetectable		 2g72A-2lf8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 10 LEU A 394
LEU A 337
VAL A 341
ILE A 402
PHE A 415
 None
 1.07A 2w9gA-2lf8A:
undetectable		 2w9gA-2lf8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 11 LEU A 394
LEU A 337
VAL A 341
ILE A 402
PHE A 415
 None
 1.09A 3frbX-2lf8A:
undetectable		 3frbX-2lf8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 9 LEU A 394
LEU A 337
VAL A 341
ILE A 402
PHE A 415
 None
 1.06A 3freX-2lf8A:
undetectable		 3freX-2lf8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 10 ILE A 354
ASN A 370
TYR A 387
ILE A 366
ARG A 410
 None
 1.24A 3u6tA-2lf8A:
undetectable		 3u6tA-2lf8A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 12 LEU A 430
LEU A 394
ILE A 402
PHE A 413
TYR A 387
 None
 1.42A 4a79A-2lf8A:
undetectable		 4a79A-2lf8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 12 LEU A 430
LEU A 394
ILE A 402
PHE A 413
TYR A 387
 None
 1.43A 4a79B-2lf8A:
undetectable		 4a79B-2lf8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 11 LEU A 430
LEU A 394
ILE A 402
PHE A 413
TYR A 387
 None
 1.43A 4a7aA-2lf8A:
undetectable		 4a7aA-2lf8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		4 / 7 ILE A 366
LEU A 372
ARG A 395
LEU A 337
 None
 0.87A 5b1aA-2lf8A:
undetectable
5b1aJ-2lf8A:
undetectable		 5b1aA-2lf8A:
12.14
5b1aJ-2lf8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		4 / 7 ILE A 366
LEU A 372
ARG A 395
LEU A 337
 None
 0.90A 5b3sA-2lf8A:
undetectable
5b3sJ-2lf8A:
undetectable		 5b3sA-2lf8A:
12.14
5b3sJ-2lf8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		3 / 3 LEU A 344
LEU A 372
ARG A 414
 None
 0.44A 5hnzB-2lf8A:
undetectable		 5hnzB-2lf8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		3 / 3 LYS A 417
LEU A 345
ILE A 363
 None
 0.74A 5kc0A-2lf8A:
undetectable		 5kc0A-2lf8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 10 PHE A 415
ILE A 402
PHE A 364
TYR A 387
GLU A 434
 None
 1.44A 5lbtA-2lf8A:
undetectable
5lbtB-2lf8A:
undetectable		 5lbtA-2lf8A:
19.17
5lbtB-2lf8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		4 / 7 LEU A 372
VAL A 437
TYR A 397
GLU A 434
 None
 1.33A 5umwA-2lf8A:
undetectable
5umwF-2lf8A:
undetectable		 5umwA-2lf8A:
23.66
5umwF-2lf8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 12 ALA A 393
LEU A 400
ILE A 422
VAL A 341
PHE A 415
 None
 1.25A 5vlmB-2lf8A:
undetectable		 5vlmB-2lf8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		4 / 7 ILE A 366
LEU A 372
ARG A 395
LEU A 337
 None
 0.92A 5zcqA-2lf8A:
undetectable
5zcqJ-2lf8A:
undetectable		 5zcqA-2lf8A:
12.14
5zcqJ-2lf8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2lf8 TRANSCRIPTION FACTOR
ETV6
(Mus
musculus) 		5 / 10 LEU A 336
GLU A 434
MET A 390
ILE A 366
LEU A 344
 None
 1.46A 6cbzB-2lf8A:
undetectable		 6cbzB-2lf8A:
23.15