SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		4 / 7 GLY A  29
GLN A  49
ILE A 107
VAL A 108
 None
 1.05A 1rxcC-2lfcA:
undetectable		 1rxcC-2lfcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		5 / 12 THR A 115
VAL A  53
ILE A  46
ILE A  32
GLN A  49
 None
 1.23A 2yzqA-2lfcA:
undetectable		 2yzqA-2lfcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		4 / 6 GLY A  29
GLN A  49
ILE A 107
VAL A 108
 None
 1.14A 3kvvD-2lfcA:
undetectable		 3kvvD-2lfcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		3 / 3 GLU A 150
TYR A  55
SER A  27
 None
 0.99A 4at0A-2lfcA:
10.4		 4at0A-2lfcA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		4 / 6 GLY A  29
GLN A  49
ILE A 107
VAL A 108
 None
 1.15A 4e1vF-2lfcA:
undetectable		 4e1vF-2lfcA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		3 / 3 LYS A  15
LEU A  70
ILE A 149
 None
 0.77A 5kc0A-2lfcA:
undetectable		 5kc0A-2lfcA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		3 / 3 LYS A  15
LEU A  70
ILE A 149
 None
 0.76A 5kc4A-2lfcA:
undetectable		 5kc4A-2lfcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT
(Lactobacillus
plantarum) 		5 / 10 ALA A   7
THR A  76
PHE A  83
PHE A  93
VAL A  92
 None
 1.48A 6hu9C-2lfcA:
undetectable		 6hu9C-2lfcA:
15.10