SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 10 LEU A  96
ALA A  94
LEU A  22
LEU A  18
LEU A  33
 None
 1.24A 1pcgA-2lfdA:
undetectable		 1pcgA-2lfdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 10 LEU A  96
ALA A  94
LEU A  22
LEU A  18
LEU A  33
 None
 1.25A 1pcgB-2lfdA:
undetectable		 1pcgB-2lfdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 11 GLU A 104
HIS A 107
GLU A  44
ILE A  70
GLU A  74
 ZN  A 400 ( 2.3A)
ZN  A 400 (-3.1A)
ZN  A 300 (-1.5A)
None
ZN  A 400 ( 2.4A)
 0.75A 1rnrA-2lfdA:
5.2		 1rnrA-2lfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 12 ASP A 103
GLU A 104
HIS A  77
GLU A  11
GLU A  74
 None
ZN  A 400 ( 2.3A)
ZN  A 300 (-3.3A)
ZN  A 400 (-1.9A)
ZN  A 400 ( 2.4A)
 1.31A 1rnrB-2lfdA:
5.1		 1rnrB-2lfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 12 GLU A 104
HIS A 107
GLU A  44
ILE A  70
GLU A  74
 ZN  A 400 ( 2.3A)
ZN  A 400 (-3.1A)
ZN  A 300 (-1.5A)
None
ZN  A 400 ( 2.4A)
 0.78A 1rnrB-2lfdA:
5.1		 1rnrB-2lfdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  11
HIS A  77
GLU A  44
 ZN  A 400 (-1.9A)
ZN  A 300 (-3.3A)
ZN  A 300 (-1.5A)
 0.87A 2x45C-2lfdA:
undetectable		 2x45C-2lfdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 11 LEU A  96
ALA A  94
LEU A  22
LEU A  18
LEU A  33
 None
 1.26A 3uudA-2lfdA:
undetectable		 3uudA-2lfdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 10 LEU A  96
ALA A  94
LEU A  22
LEU A  18
LEU A  33
 None
 1.22A 5dxeB-2lfdA:
undetectable		 5dxeB-2lfdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  14
ALA A  10
LEU A   7
GLU A  74
VAL A  50
 None
None
None
ZN  A 400 ( 2.4A)
None
 1.24A 5hw4A-2lfdA:
undetectable		 5hw4A-2lfdA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2lfd DIIRON PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  14
ALA A  10
LEU A   7
GLU A  74
VAL A  50
 None
None
None
ZN  A 400 ( 2.4A)
None
 1.23A 5hw4C-2lfdA:
undetectable		 5hw4C-2lfdA:
17.60