SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	2lfs	UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA (Shigella flexneri; Archaeoglobus fulgidus)	4 / 8	SER A 288 PHE A 291 ASN A 289 ASP A 292	None	1.35A	1zzuA-2lfsA: undetectable	1zzuA-2lfsA: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_A_MTLA870_0 (NITRIC OXIDE SYNTHASE)	2lfs	UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA (Shigella flexneri; Archaeoglobus fulgidus)	4 / 8	SER A 288 PHE A 291 ASN A 289 ASP A 292	None	1.08A	3n62A-2lfsA: undetectable	3n62A-2lfsA: 14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_B_MTLB870_0 (NITRIC OXIDE SYNTHASE)	2lfs	UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA (Shigella flexneri; Archaeoglobus fulgidus)	4 / 8	SER A 288 PHE A 291 ASN A 289 ASP A 292	None	1.31A	3n62B-2lfsA: undetectable	3n62B-2lfsA: 14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWJ_B_30ZB201_1 (TRANSTHYRETIN)	2lfs	UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA (Archaeoglobus fulgidus; Shigella flexneri)	4 / 7	THR A 334 ALA A 330 LEU A 326 SER A 325	None	1.04A	4pwjB-2lfsA: undetectable	4pwjB-2lfsA: 18.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ZZU_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","2lfs","UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA","Shigella flexneri;Archaeoglobus fulgidus",4,"SER A 288;PHE A 291;ASN A 289;ASP A 292","None","1.35A","1zzuA-2lfsA:undetectable","1zzuA-2lfsA:13.98"],["3N62_A_MTLA870_0","NITRIC OXIDE SYNTHASE","2lfs","UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA","Shigella flexneri;Archaeoglobus fulgidus",4,"SER A 288;PHE A 291;ASN A 289;ASP A 292","None","1.08A","3n62A-2lfsA:undetectable","3n62A-2lfsA:14.55"],["3N62_B_MTLB870_0","NITRIC OXIDE SYNTHASE","2lfs","UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA","Shigella flexneri;Archaeoglobus fulgidus",4,"SER A 288;PHE A 291;ASN A 289;ASP A 292","None","1.31A","3n62B-2lfsA:undetectable","3n62B-2lfsA:14.55"],["4PWJ_B_30ZB201_1","TRANSTHYRETIN","2lfs","UNCHARACTERIZED PROTEIN, OSMOLARITY SENSOR PROTEIN ENVZ CHIMERA","Archaeoglobus fulgidus;Shigella flexneri",4,"THR A 334;ALA A 330;LEU A 326;SER A 325","None","1.04A","4pwjB-2lfsA:undetectable","4pwjB-2lfsA:18.62"]]