SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 12 VAL A 401
GLY A 376
ALA A 314
GLY A 315
ILE A 372
 None
 0.82A 3ku1A-2lfuA:
undetectable		 3ku1A-2lfuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 12 VAL A 401
GLY A 376
ALA A 314
GLY A 315
ILE A 372
 None
 0.83A 3ku1C-2lfuA:
undetectable		 3ku1C-2lfuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 12 VAL A 401
GLY A 376
ALA A 314
GLY A 315
ILE A 372
 None
 0.77A 3ku1G-2lfuA:
undetectable		 3ku1G-2lfuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 12 ALA A 341
TYR A 319
VAL A 318
PHE A 420
GLY A 321
 None
 1.12A 4mm4B-2lfuA:
undetectable		 4mm4B-2lfuA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 12 ALA A 341
TYR A 319
GLY A 403
PHE A 420
GLY A 321
 None
 1.19A 4mmdB-2lfuA:
undetectable		 4mmdB-2lfuA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 9 ALA A 341
TYR A 319
GLY A 403
PHE A 420
GLY A 321
 None
 1.19A 4mmeA-2lfuA:
undetectable		 4mmeA-2lfuA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 9 ALA A 341
TYR A 319
GLY A 403
PHE A 420
GLY A 321
 None
 1.18A 4mmfA-2lfuA:
undetectable		 4mmfA-2lfuA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2lfu GNA2132
(Neisseria
meningitidis) 		5 / 11 PHE A 420
VAL A 351
ASP A 352
GLY A 403
GLY A 353
 None
 1.25A 4xp4A-2lfuA:
undetectable		 4xp4A-2lfuA:
14.26