SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	2lg1	A-KINASE ANCHOR PROTEIN 13 (Homo sapiens)	3 / 3	LYS A 56 ASP A 179 ASP A 177	None	0.95A	2br4A-2lg1A: undetectable	2br4A-2lg1A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_A_RITA600_2 (CYTOCHROME P450 3A4)	2lg1	A-KINASE ANCHOR PROTEIN 13 (Homo sapiens)	4 / 7	PHE A 61 LEU A 71 THR A 47 THR A 170	None	1.10A	3nxuA-2lg1A: undetectable	3nxuA-2lg1A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5W_A_8PRA701_2 (G-PROTEIN COUPLED RECEPTOR KINASE 2)	2lg1	A-KINASE ANCHOR PROTEIN 13 (Homo sapiens)	3 / 3	LEU A 113 MET A 53 ASP A 48	None	0.78A	3v5wA-2lg1A: 9.0	3v5wA-2lg1A: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2lg1	A-KINASE ANCHOR PROTEIN 13 (Homo sapiens)	5 / 12	ILE A 97 VAL A 89 ALA A 91 LEU A 93 LEU A 94	None	0.92A	4m11C-2lg1A: undetectable	4m11C-2lg1A: 16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLO_A_GBQA1501_1 (SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR)	2lg1	A-KINASE ANCHOR PROTEIN 13 (Homo sapiens)	5 / 9	ILE A 164 ILE A 166 GLU A 151 VAL A 127 ILE A 167	None	1.40A	6hloA-2lg1A: undetectable	6hloA-2lg1A: 18.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BR4_A_SAMA301_1","CEPHALOSPORIN HYDROXYLASE CMCI","2lg1","A-KINASE ANCHOR PROTEIN 13","Homo sapiens",3,"LYS A  56;ASP A 179;ASP A 177","None","0.95A","2br4A-2lg1A:undetectable","2br4A-2lg1A:18.91"],["3NXU_A_RITA600_2","CYTOCHROME P450 3A4","2lg1","A-KINASE ANCHOR PROTEIN 13","Homo sapiens",4,"PHE A  61;LEU A  71;THR A  47;THR A 170","None","1.10A","3nxuA-2lg1A:undetectable","3nxuA-2lg1A:18.91"],["3V5W_A_8PRA701_2","G-PROTEIN COUPLED RECEPTOR KINASE 2","2lg1","A-KINASE ANCHOR PROTEIN 13","Homo sapiens",3,"LEU A 113;MET A  53;ASP A  48","None","0.78A","3v5wA-2lg1A:9.0","3v5wA-2lg1A:16.36"],["4M11_C_MXMC606_1","PROSTAGLANDIN G\/H SYNTHASE 2","2lg1","A-KINASE ANCHOR PROTEIN 13","Homo sapiens",5,"ILE A  97;VAL A  89;ALA A  91;LEU A  93;LEU A  94","None","0.92A","4m11C-2lg1A:undetectable","4m11C-2lg1A:16.54"],["6HLO_A_GBQA1501_1","SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR","2lg1","A-KINASE ANCHOR PROTEIN 13","Homo sapiens",5,"ILE A 164;ILE A 166;GLU A 151;VAL A 127;ILE A 167","None","1.40A","6hloA-2lg1A:undetectable","6hloA-2lg1A:18.28"]]