SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  28
VAL A  24
TRP A  23
 None
 0.96A 1gmkA-2lgzA:
undetectable
1gmkB-2lgzA:
undetectable		 1gmkA-2lgzA:
3.66
1gmkB-2lgzA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  28
VAL A  24
TRP A  23
 None
 0.87A 1gmkC-2lgzA:
undetectable
1gmkD-2lgzA:
undetectable		 1gmkC-2lgzA:
3.66
1gmkD-2lgzA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 SER A 227
VAL A 232
ASN A 181
LYS A   1
 None
 1.06A 1hwiB-2lgzA:
undetectable		 1hwiB-2lgzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 248
VAL A  68
TRP A  72
 None
 1.07A 1zviA-2lgzA:
undetectable		 1zviA-2lgzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 251
GLU A 252
ASP A  73
ASP A 222
 None
 1.36A 3mb5A-2lgzA:
undetectable		 3mb5A-2lgzA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  74
TYR A  29
GLU A 223
 None
 0.92A 3pfgA-2lgzA:
undetectable		 3pfgA-2lgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 223
HIS A  97
GLN A  77
GLY A  75
 None
 0.99A 4f93B-2lgzA:
undetectable		 4f93B-2lgzA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  51
SER A  30
HIS A   7
ASP A 122
 None
 1.16A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 128
SER A  30
HIS A   7
ASP A 122
 None
 1.33A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 174
ARG A 170
GLY A 167
GLU A 168
 None
 1.06A 5cdqA-2lgzA:
undetectable
5cdqC-2lgzA:
undetectable
5cdqD-2lgzA:
undetectable		 5cdqA-2lgzA:
21.72
5cdqC-2lgzA:
21.72
5cdqD-2lgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 199
ARG A 204
GLN A 207
TYR A 235
 None
 1.05A 5vlmB-2lgzA:
undetectable		 5vlmB-2lgzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  48
GLU A 118
HIS A 119
TRP A  72
 None
 0.93A 6j20A-2lgzA:
undetectable		 6j20A-2lgzA:
22.25