SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		5 / 11 PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
 None
 0.85A 1dtlA-2lhiA:
12.5		 1dtlA-2lhiA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		5 / 12 ALA A  15
PHE A  19
PHE A  68
MET A  72
LEU A 109
 None
 1.14A 1dtlA-2lhiA:
12.5		 1dtlA-2lhiA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA155_1
(CALMODULIN)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		4 / 7 GLN A  83
GLU A  87
PHE A  19
MET A  72
 None
 1.35A 1linA-2lhiA:
15.1		 1linA-2lhiA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		5 / 8 ILE A 100
LEU A 105
MET A 124
GLU A 127
VAL A 128
 None
 0.97A 1linA-2lhiA:
15.1		 1linA-2lhiA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		4 / 6 ALA A 464
ILE A 112
VAL A  35
PHE A  19
 None
 0.82A 2cizA-2lhiA:
undetectable		 2cizA-2lhiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		5 / 12 LEU A  69
LEU A 463
ALA A 464
LEU A  76
PHE A  16
 None
 1.33A 2oaxB-2lhiA:
undetectable		 2oaxB-2lhiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		6 / 12 LEU A  69
LEU A 463
ALA A 464
MET A 471
LEU A  76
PHE A  16
 None
 1.27A 2oaxE-2lhiA:
undetectable		 2oaxE-2lhiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		5 / 12 ILE A 135
GLN A 138
GLN A 139
ALA A 142
LEU A 143
 None
 0.91A 3ozwB-2lhiA:
undetectable		 3ozwB-2lhiA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		3 / 3 SER A  66
PHE A  12
LYS A  13
 None
 1.00A 3u88A-2lhiA:
undetectable		 3u88A-2lhiA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		4 / 6 ASN A 460
GLU A  14
GLU A  11
GLU A   7
 None
 1.48A 4r87H-2lhiA:
undetectable		 4r87H-2lhiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		3 / 3 MET A  72
GLN A  75
ARG A  74
 None
 1.13A 6fn9A-2lhiA:
undetectable		 6fn9A-2lhiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		3 / 3 MET A  72
GLN A  75
ARG A  74
 None
 1.14A 6fnaB-2lhiA:
undetectable		 6fnaB-2lhiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1
(Saccharomyces
cerevisiae;
synthetic
construct) 		3 / 3 MET A  72
GLN A  75
ARG A  74
 None
 1.13A 6fnbA-2lhiA:
undetectable		 6fnbA-2lhiA:
24.56