SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA8_0
(GRAMICIDIN A)		 2lhs CBP21
(Serratia
marcescens) 		4 / 4 GLY A   2
VAL A   4
TRP A 151
TRP A  92
 None
 1.42A 1magA-2lhsA:
undetectable		 1magA-2lhsA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB8_0
(GRAMICIDIN A)		 2lhs CBP21
(Serratia
marcescens) 		4 / 4 GLY A   2
VAL A   4
TRP A 151
TRP A  92
 None
 1.42A 1magB-2lhsA:
undetectable		 1magB-2lhsA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2lhs CBP21
(Serratia
marcescens) 		3 / 3 ILE A 147
ASP A 113
PHE A 112
 None
 0.63A 1uwjB-2lhsA:
undetectable		 1uwjB-2lhsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2lhs CBP21
(Serratia
marcescens) 		5 / 12 ILE A 164
PHE A  79
LEU A 168
PHE A 117
ILE A 137
 None
 1.15A 2y7kD-2lhsA:
undetectable		 2y7kD-2lhsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2lhs CBP21
(Serratia
marcescens) 		3 / 3 GLN A 130
THR A 132
THR A  80
 None
 0.82A 4fu9A-2lhsA:
undetectable		 4fu9A-2lhsA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2lhs CBP21
(Serratia
marcescens) 		3 / 3 GLN A 130
THR A 132
THR A  80
 None
 0.81A 4fufA-2lhsA:
undetectable		 4fufA-2lhsA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2lhs CBP21
(Serratia
marcescens) 		5 / 12 GLY A  37
GLY A  42
ALA A  51
ALA A 157
ASP A 152
 None
 1.21A 4kicA-2lhsA:
undetectable		 4kicA-2lhsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2lhs CBP21
(Serratia
marcescens) 		5 / 12 PRO A 138
SER A  78
SER A   6
PHE A  79
ILE A 164
 None
 1.34A 4ktvA-2lhsA:
0.0
4ktvB-2lhsA:
0.0		 4ktvA-2lhsA:
16.04
4ktvB-2lhsA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.42A 4qvlV-2lhsA:
undetectable
4qvlb-2lhsA:
undetectable		 4qvlV-2lhsA:
19.41
4qvlb-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.42A 4qvlH-2lhsA:
undetectable
4qvlN-2lhsA:
undetectable		 4qvlH-2lhsA:
19.41
4qvlN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 10 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.35A 4qvvH-2lhsA:
undetectable
4qvvN-2lhsA:
undetectable		 4qvvH-2lhsA:
19.41
4qvvN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 10 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.45A 4qvvH-2lhsA:
undetectable
4qvvN-2lhsA:
undetectable		 4qvvH-2lhsA:
19.41
4qvvN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.38A 4qvwV-2lhsA:
undetectable
4qvwb-2lhsA:
undetectable		 4qvwV-2lhsA:
19.41
4qvwb-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.46A 4qvwV-2lhsA:
undetectable
4qvwb-2lhsA:
undetectable		 4qvwV-2lhsA:
19.41
4qvwb-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.37A 4qvwH-2lhsA:
undetectable
4qvwN-2lhsA:
undetectable		 4qvwH-2lhsA:
19.41
4qvwN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.47A 4qvwH-2lhsA:
undetectable
4qvwN-2lhsA:
undetectable		 4qvwH-2lhsA:
19.41
4qvwN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.35A 4qw0V-2lhsA:
undetectable
4qw0b-2lhsA:
undetectable		 4qw0V-2lhsA:
19.41
4qw0b-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.45A 4qw0V-2lhsA:
undetectable
4qw0b-2lhsA:
undetectable		 4qw0V-2lhsA:
19.41
4qw0b-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.35A 4qw0H-2lhsA:
undetectable
4qw0N-2lhsA:
undetectable		 4qw0H-2lhsA:
19.41
4qw0N-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.44A 4qw0H-2lhsA:
undetectable
4qw0N-2lhsA:
undetectable		 4qw0H-2lhsA:
19.41
4qw0N-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.42A 4qw1V-2lhsA:
undetectable
4qw1b-2lhsA:
undetectable		 4qw1V-2lhsA:
19.41
4qw1b-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.42A 4qw1H-2lhsA:
undetectable
4qw1N-2lhsA:
undetectable		 4qw1H-2lhsA:
19.41
4qw1N-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.34A 4qwuV-2lhsA:
undetectable
4qwub-2lhsA:
undetectable		 4qwuV-2lhsA:
19.41
4qwub-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.46A 4qwuV-2lhsA:
undetectable
4qwub-2lhsA:
undetectable		 4qwuV-2lhsA:
19.41
4qwub-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
 None
 1.35A 4qwuH-2lhsA:
undetectable
4qwuN-2lhsA:
undetectable		 4qwuH-2lhsA:
19.41
4qwuN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		5 / 11 SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.47A 4qwuH-2lhsA:
undetectable
4qwuN-2lhsA:
undetectable		 4qwuH-2lhsA:
19.41
4qwuN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2lhs CBP21
(Serratia
marcescens) 		5 / 12 SER A  78
ILE A 137
PRO A 138
ASP A 140
ILE A 147
 None
 1.30A 4uroA-2lhsA:
undetectable		 4uroA-2lhsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2lhs CBP21
(Serratia
marcescens) 		5 / 12 SER A  78
ILE A 137
PRO A 138
ASP A 140
ILE A 147
 None
 1.30A 4uroD-2lhsA:
undetectable		 4uroD-2lhsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.43A 5bxnV-2lhsA:
undetectable
5bxnb-2lhsA:
undetectable		 5bxnV-2lhsA:
20.82
5bxnb-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2lhs CBP21
(Serratia
marcescens) 		6 / 11 HIS A  47
SER A  50
THR A  97
THR A 108
ARG A  10
ALA A  49
 None
 1.43A 5bxnH-2lhsA:
undetectable
5bxnN-2lhsA:
undetectable		 5bxnH-2lhsA:
20.82
5bxnN-2lhsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2lhs CBP21
(Serratia
marcescens) 		5 / 9 THR A  55
SER A  50
VAL A  32
ALA A  11
SER A   9
 None
 1.21A 5l5fK-2lhsA:
undetectable
5l5fL-2lhsA:
undetectable		 5l5fK-2lhsA:
22.12
5l5fL-2lhsA:
22.22