SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		3 / 3 GLN A  49
PHE A 107
TYR A 168
 None
 0.88A 3ucjB-2ligA:
undetectable		 3ucjB-2ligA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		3 / 3 GLN A  49
PHE A 107
TYR A 168
 None
 0.91A 3ucjA-2ligA:
undetectable		 3ucjA-2ligA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		4 / 4 ALA A  98
ALA A 101
ALA A 102
ALA A 105
 None
 0.12A 4oaeA-2ligA:
undetectable		 4oaeA-2ligA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		5 / 10 GLY A 162
ALA A 100
LEU A 161
LEU A 165
TYR A 127
 None
 1.20A 4xj7A-2ligA:
undetectable
4xj7B-2ligA:
undetectable		 4xj7A-2ligA:
21.53
4xj7B-2ligA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		5 / 12 PRO A 112
VAL A 123
SER A 120
TYR A 168
LEU A  46
 None
 1.32A 4xrgA-2ligA:
undetectable		 4xrgA-2ligA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		4 / 6 ALA A 101
GLN A 131
GLN A 128
ASP A 124
 None
 1.43A 5y9aA-2ligA:
undetectable		 5y9aA-2ligA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2lig ASPARTATE RECEPTOR
(Salmonella
enterica) 		3 / 3 TYR A 130
ALA A 164
LEU A 165
 None
 0.60A 6ag0C-2ligA:
undetectable		 6ag0C-2ligA:
21.38