SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2liv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2liv LEUCINE
(Escherichia
coli) 		4 / 7 PHE A 196
VAL A 331
VAL A 158
ILE A 132
 None
 0.99A 1p7rA-2livA:
undetectable		 1p7rA-2livA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.05A 1rs7B-2livA:
undetectable		 1rs7B-2livA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2liv LEUCINE
(Escherichia
coli) 		4 / 7 PHE A 196
VAL A 331
VAL A 158
ILE A 132
 None
 0.98A 1t87B-2livA:
undetectable		 1t87B-2livA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 PHE A 182
ILE A 209
GLY A 201
GLY A 200
 None
 0.83A 2qx6A-2livA:
4.1
2qx6B-2livA:
3.0		 2qx6A-2livA:
20.69
2qx6B-2livA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2liv LEUCINE
(Escherichia
coli) 		4 / 8 LEU A 324
THR A  98
ALA A 282
ALA A 283
 None
 1.02A 3ax9B-2livA:
undetectable		 3ax9B-2livA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 2liv LEUCINE
(Escherichia
coli) 		4 / 7 VAL A   7
VAL A   8
GLY A  75
PRO A  99
 None
 0.96A 3bjwC-2livA:
undetectable		 3bjwC-2livA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 TYR A 198
TYR A 150
GLY A 224
 None
 0.72A 3eteB-2livA:
6.4
3eteD-2livA:
3.9
3eteF-2livA:
6.3		 3eteB-2livA:
20.80
3eteD-2livA:
20.80
3eteF-2livA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2liv LEUCINE
(Escherichia
coli) 		4 / 8 VAL A  73
HIS A  76
THR A  82
VAL A   8
 None
 1.09A 3fhxB-2livA:
2.8		 3fhxB-2livA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 SER A 183
GLN A 212
PHE A 182
 None
 0.58A 3g4lC-2livA:
undetectable		 3g4lC-2livA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.01A 4d39B-2livA:
undetectable		 4d39B-2livA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2liv LEUCINE
(Escherichia
coli) 		5 / 10 ALA A 283
LEU A 284
VAL A  30
ILE A   3
ALA A  47
 None
 1.08A 4j14A-2livA:
undetectable		 4j14A-2livA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 GLY A  25
ILE A 265
GLN A  28
VAL A 312
 None
 1.01A 4kcnA-2livA:
undetectable		 4kcnA-2livA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.79A 4olbA-2livA:
4.5		 4olbA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.66A 4w5nA-2livA:
4.7		 4w5nA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 LEU A 154
TYR A 199
PRO A 225
TYR A 150
 None
 1.32A 4z4gA-2livA:
4.9		 4z4gA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.79A 4z4iA-2livA:
4.9		 4z4iA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2liv LEUCINE
(Escherichia
coli) 		5 / 10 MET A  96
LEU A 287
ALA A 283
GLY A   9
HIS A  76
 None
 1.41A 5dx3A-2livA:
undetectable		 5dx3A-2livA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2liv LEUCINE
(Escherichia
coli) 		4 / 6 ILE A 141
ALA A 155
VAL A 158
HIS A 145
 None
 0.76A 5eclD-2livA:
undetectable		 5eclD-2livA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 VAL A   8
ALA A  10
PHE A  23
 None
 0.78A 5js1A-2livA:
4.6		 5js1A-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2liv LEUCINE
(Escherichia
coli) 		3 / 3 LEU A 185
SER A 183
PHE A 182
 None
 0.63A 6fgcA-2livA:
5.5		 6fgcA-2livA:
22.37