SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LOQ_A_ACTA278_0 (UNIVERSAL STRESS PROTEIN)	2lj4	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE/ROTAMASE, PUTATIVE (Trypanosoma brucei)	3 / 3	SER A 63 GLY A 74 SER A 57	None	0.65A	3loqA-2lj4A: undetectable	3loqA-2lj4A: 19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4TNS_A_REAA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1)	2lj4	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE/ROTAMASE, PUTATIVE (Trypanosoma brucei)	5 / 9	HIS A 12 LYS A 16 MET A 85 PHE A 89 HIS A 112	None	1.04A	4tnsA-2lj4A: 18.2	4tnsA-2lj4A: 39.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WWS_B_SAMB501_0 (PUTATIVE METHYLTRANSFERASE NSUN6)	2lj4	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE/ROTAMASE, PUTATIVE (Trypanosoma brucei)	5 / 12	GLY A 110 LYS A 16 ASP A 76 GLY A 74 ASP A 67	None	1.19A	5wwsB-2lj4A: undetectable	5wwsB-2lj4A: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_E_AM2E301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	2lj4	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE/ROTAMASE, PUTATIVE (Trypanosoma brucei)	4 / 7	HIS A 112 THR A 107 ARG A 26 ASP A 67	None	1.04A	6mn4E-2lj4A: undetectable	6mn4E-2lj4A: 18.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LOQ_A_ACTA278_0","UNIVERSAL STRESS PROTEIN","2lj4","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE\/ROTAMASE, PUTATIVE","Trypanosoma brucei",3,"SER A  63;GLY A  74;SER A  57","None","0.65A","3loqA-2lj4A:undetectable","3loqA-2lj4A:19.84"],["4TNS_A_REAA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","2lj4","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE\/ROTAMASE, PUTATIVE","Trypanosoma brucei",5,"HIS A  12;LYS A  16;MET A  85;PHE A  89;HIS A 112","None","1.04A","4tnsA-2lj4A:18.2","4tnsA-2lj4A:39.87"],["5WWS_B_SAMB501_0","PUTATIVE METHYLTRANSFERASE NSUN6","2lj4","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE\/ROTAMASE, PUTATIVE","Trypanosoma brucei",5,"GLY A 110;LYS A  16;ASP A  76;GLY A  74;ASP A  67","None","1.19A","5wwsB-2lj4A:undetectable","5wwsB-2lj4A:14.01"],["6MN4_E_AM2E301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","2lj4","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE\/ROTAMASE, PUTATIVE","Trypanosoma brucei",4,"HIS A 112;THR A 107;ARG A  26;ASP A  67","None","1.04A","6mn4E-2lj4A:undetectable","6mn4E-2lj4A:18.65"]]