SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 PHE A  57
ILE A  36
TYR A  34
GLY A  54
 None
 0.84A 11gsA-2lj8A:
undetectable		 11gsA-2lj8A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 PHE A  57
ILE A  36
TYR A  34
GLY A  54
 None
 0.84A 11gsB-2lj8A:
undetectable		 11gsB-2lj8A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		5 / 10 LEU A  27
LEU A  88
ILE A  91
THR A  49
ILE A  36
 None
 1.38A 1i18A-2lj8A:
undetectable
1i18B-2lj8A:
undetectable		 1i18A-2lj8A:
20.57
1i18B-2lj8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A  57
ILE A  36
TYR A  34
GLY A  54
 None
 0.89A 2gssA-2lj8A:
undetectable		 2gssA-2lj8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A  57
ILE A  36
TYR A  34
GLY A  54
 None
 0.89A 2gssB-2lj8A:
undetectable		 2gssB-2lj8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 TYR A 106
VAL A 114
ALA A 112
SER A 107
SER A 108
 None
 1.22A 4mmaA-2lj8A:
undetectable		 4mmaA-2lj8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 THR A  49
MET A  37
HIS A  38
 None
 0.45A 5uunA-2lj8A:
undetectable		 5uunA-2lj8A:
18.39