SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  24
ALA A  27
ALA A 152
LEU A 150
ILE A 111
 None
None
GDP  A 179 (-3.1A)
None
None
 1.01A 1fk6A-2lkdA:
undetectable		 1fk6A-2lkdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A  13
PHE A  59
VAL A  52
SER A  31
 None
 1.11A 1kb9A-2lkdA:
undetectable
1kb9C-2lkdA:
undetectable
1kb9D-2lkdA:
undetectable
1kb9E-2lkdA:
undetectable		 1kb9A-2lkdA:
16.40
1kb9C-2lkdA:
17.31
1kb9D-2lkdA:
20.08
1kb9E-2lkdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  24
ILE A  13
GLY A  15
ASP A  90
GLY A  91
 None
 1.12A 1zz1C-2lkdA:
undetectable		 1zz1C-2lkdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A  83
ASP A  61
LEU A  60
PHE A  59
 None
 0.90A 2tsrB-2lkdA:
undetectable		 2tsrB-2lkdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 174
ASP A  54
LYS A 175
GLU A 173
 None
 1.33A 2vn1B-2lkdA:
undetectable		 2vn1B-2lkdA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A  83
ILE A  57
PHE A  59
GLU A 163
 None
 0.83A 3ua5A-2lkdA:
undetectable		 3ua5A-2lkdA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A  59
THR A 145
LEU A 161
 None
 0.77A 4qztA-2lkdA:
undetectable		 4qztA-2lkdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A  19
GLY A  20
VAL A  85
ASP A  90
ASN A 115
 None
GDP  A 179 (-3.0A)
None
None
GDP  A 179 (-3.6A)
 1.50A 5f8yA-2lkdA:
undetectable		 5f8yA-2lkdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2lkd TRANSLATION
INITIATION FACTOR
IF-2
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A  82
ILE A 110
LEU A 136
PHE A 147
GLY A  15
 None
 1.20A 5mxbA-2lkdA:
undetectable		 5mxbA-2lkdA:
18.99