SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		3 / 3 VAL A  82
GLU A  67
GLU A  68
 None
 0.65A 2nv4A-2lkkA:
undetectable		 2nv4A-2lkkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		4 / 6 GLU A  13
MET A  19
PHE A 120
ILE A 118
 None
OLA  A 128 (-3.5A)
OLA  A 128 ( 4.3A)
None
 1.34A 2w98B-2lkkA:
undetectable		 2w98B-2lkkA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 PHE A  63
THR A  73
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 3.9A)
None
None
None
OLA  A 129 (-2.7A)
 0.78A 3elzA-2lkkA:
16.2		 3elzA-2lkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 ILE A  22
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
None
None
None
OLA  A 129 (-2.7A)
 0.87A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 PHE A  18
ILE A  22
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 4.8A)
None
None
None
OLA  A 129 (-2.7A)
 0.56A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3o1xA-2lkkA:
undetectable		 3o1xA-2lkkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3qgzA-2lkkA:
undetectable		 3qgzA-2lkkA:
17.83