SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS B 188
ASP B 208
ASP B 196
 None
 0.81A 2br4D-2lkmB:
undetectable		 2br4D-2lkmB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2lkm PHD FINGER PROTEIN
12
MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLU A 219
ALA A 217
THR B 277
ILE A 214
 None
 0.82A 2dtjA-2lkmA:
undetectable
2dtjB-2lkmA:
undetectable		 2dtjA-2lkmA:
14.73
2dtjB-2lkmA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2lkm PHD FINGER PROTEIN
12
MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A 213
THR B 231
PRO A 222
ASN A 221
LEU B 263
 None
 1.36A 2ft9A-2lkmA:
undetectable		 2ft9A-2lkmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 234
LEU B 233
VAL B 257
MET B 254
LEU B 184
 None
 1.14A 2q7kA-2lkmB:
undetectable		 2q7kA-2lkmB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO B 240
GLU B 317
TYR B 318
 None
 0.78A 2zmbA-2lkmB:
undetectable		 2zmbA-2lkmB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR B 318
HIS B 319
PHE B 237
 None
 0.87A 6esmA-2lkmB:
undetectable		 6esmA-2lkmB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR B 258
ILE B 193
MET B 228
GLY B 230
 None
 0.82A 6hd6B-2lkmB:
undetectable		 6hd6B-2lkmB:
16.18