SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 7 PHE A 150
LEU A  62
ALA A  34
PHE A  36
VAL A 157
 None
 1.46A 1epbA-2lknA:
undetectable		 1epbA-2lknA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 101
LEU A 105
MET A  60
PHE A 150
MET A 152
 None
 1.40A 2jj8C-2lknA:
undetectable		 2jj8C-2lknA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 LYS A 103
LEU A 100
ALA A 102
LEU A  97
 None
 1.40A 2roxA-2lknA:
undetectable		 2roxA-2lknA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 ARG A  81
GLY A  83
GLU A  20
GLU A  84
 None
 0.84A 3k9fA-2lknA:
undetectable
3k9fB-2lknA:
undetectable
3k9fD-2lknA:
undetectable		 3k9fA-2lknA:
16.45
3k9fB-2lknA:
16.45
3k9fD-2lknA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 LYS A  69
LYS A 103
SER A 104
 None
 1.15A 5odiA-2lknA:
undetectable		 5odiA-2lknA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 GLN A 143
LEU A 141
ASN A 144
GLN A 146
 None
 1.05A 5vw3A-2lknA:
0.0		 5vw3A-2lknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  81
GLY A  23
GLU A  24
 None
 0.54A 6fgdA-2lknA:
undetectable		 6fgdA-2lknA:
17.39