SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UW6_D_NCTD1208_1 (ACETYLCHOLINE-BINDIN G PROTEIN)	2lla	MANNOSE-6-PHOSPHATE/ INSULIN-LIKE GROWTH FACTOR II RECEPTOR (Tachyglossus aculeatus)	4 / 8	TYR A1516 TRP A1618 THR A1620 LEU A1566	None	1.39A	1uw6D-2llaA: undetectable 1uw6E-2llaA: undetectable	1uw6D-2llaA: 20.20 1uw6E-2llaA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UW6_P_NCTP1206_1 (ACETYLCHOLINE-BINDIN G PROTEIN)	2lla	MANNOSE-6-PHOSPHATE/ INSULIN-LIKE GROWTH FACTOR II RECEPTOR (Tachyglossus aculeatus)	4 / 8	TYR A1516 TRP A1618 THR A1620 LEU A1566	None	1.36A	1uw6P-2llaA: undetectable 1uw6Q-2llaA: undetectable	1uw6P-2llaA: 20.20 1uw6Q-2llaA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_A_TLFA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2lla	MANNOSE-6-PHOSPHATE/ INSULIN-LIKE GROWTH FACTOR II RECEPTOR (Tachyglossus aculeatus)	3 / 3	LEU A1507 TYR A1516 SER A1600	None	0.80A	5iktA-2llaA: undetectable	5iktA-2llaA: 13.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UW6_D_NCTD1208_1","ACETYLCHOLINE-BINDING PROTEIN;ACETYLCHOLINE-BINDING PROTEIN","2lla","MANNOSE-6-PHOSPHATE\/INSULIN-LIKE GROWTH FACTOR II RECEPTOR","Tachyglossus aculeatus",4,"TYR A1516;TRP A1618;THR A1620;LEU A1566","None","1.39A","1uw6D-2llaA:undetectable;1uw6E-2llaA:undetectable","1uw6D-2llaA:20.20;1uw6E-2llaA:20.20"],["1UW6_P_NCTP1206_1","ACETYLCHOLINE-BINDING PROTEIN;ACETYLCHOLINE-BINDING PROTEIN","2lla","MANNOSE-6-PHOSPHATE\/INSULIN-LIKE GROWTH FACTOR II RECEPTOR","Tachyglossus aculeatus",4,"TYR A1516;TRP A1618;THR A1620;LEU A1566","None","1.36A","1uw6P-2llaA:undetectable;1uw6Q-2llaA:undetectable","1uw6P-2llaA:20.20;1uw6Q-2llaA:20.20"],["5IKT_A_TLFA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2lla","MANNOSE-6-PHOSPHATE\/INSULIN-LIKE GROWTH FACTOR II RECEPTOR","Tachyglossus aculeatus",3,"LEU A1507;TYR A1516;SER A1600","None","0.80A","5iktA-2llaA:undetectable","5iktA-2llaA:13.62"]]