SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 ILE A 211
LEU A 216
ALA A 202
VAL A 205
 None
 0.73A 1a29A-2lleA:
undetectable		 1a29A-2lleA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		5 / 8 ILE A 177
LEU A 149
MET A 165
ILE A 166
GLU A 164
 None
 1.05A 1linA-2lleA:
undetectable		 1linA-2lleA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		5 / 12 LEU A 216
ILE A   4
GLY A   2
PHE A 193
GLY A 224
 None
 0.85A 1zz1C-2lleA:
undetectable		 1zz1C-2lleA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 6 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 0.98A 2dcfA-2lleA:
undetectable		 2dcfA-2lleA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 7 GLU A 140
TRP A 135
PRO A  89
GLY A 143
 None
 1.22A 2hs1B-2lleA:
undetectable		 2hs1B-2lleA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 SER A 151
LEU A 149
ASP A 162
ASP A 153
 None
 1.10A 2j2pA-2lleA:
undetectable
2j2pB-2lleA:
undetectable		 2j2pA-2lleA:
18.33
2j2pB-2lleA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		3 / 3 GLY A 181
TYR A 161
SER A 180
 None
 0.63A 2xatA-2lleA:
undetectable		 2xatA-2lleA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 7 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 1.00A 2zm7A-2lleA:
undetectable		 2zm7A-2lleA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 0.99A 2zm8A-2lleA:
undetectable		 2zm8A-2lleA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 0.98A 2zmaA-2lleA:
undetectable		 2zmaA-2lleA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		3 / 3 SER A 151
GLU A 164
ASP A 153
 None
 0.79A 2zthA-2lleA:
3.3		 2zthA-2lleA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 PHE A 206
ALA A 202
ALA A 200
LEU A 220
 None
 0.98A 3l4dA-2lleA:
undetectable		 3l4dA-2lleA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 8 PHE A 206
ALA A 202
ALA A 200
LEU A 220
 None
 0.99A 3l4dD-2lleA:
undetectable		 3l4dD-2lleA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		5 / 10 GLY A 145
ALA A 144
ILE A  80
LEU A  91
ILE A  92
 None
 0.98A 3ttpA-2lleA:
undetectable		 3ttpA-2lleA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		5 / 10 TYR A 161
VAL A 205
PHE A 189
SER A 180
GLY A 182
 None
 1.42A 4mm7A-2lleA:
undetectable		 4mm7A-2lleA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		3 / 3 ILE A  33
ILE A  80
MET A  67
 None
 0.68A 5i9yA-2lleA:
undetectable		 5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		3 / 3 ILE A  41
ILE A  56
MET A  67
 None
 0.69A 5i9yA-2lleA:
undetectable		 5i9yA-2lleA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA
(Thermotoga
maritima) 		4 / 7 ILE A 177
LEU A 132
PHE A 117
ARG A 154
 None
 0.97A 5vc0A-2lleA:
undetectable		 5vc0A-2lleA:
19.03