SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		3 / 3 GLU A1509
GLU A1563
LEU A1517
 None
 0.72A 1v8bA-2lm0A:
undetectable		 1v8bA-2lm0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		3 / 3 GLU A1509
GLU A1563
LEU A1517
 None
 0.77A 1v8bB-2lm0A:
undetectable		 1v8bB-2lm0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		4 / 6 LEU A 770
SER A 771
ARG A 772
LEU A 767
 None
 1.01A 3f33A-2lm0A:
undetectable		 3f33A-2lm0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		4 / 6 LEU A 770
SER A 771
ARG A 772
LEU A 767
 None
 1.02A 3ravA-2lm0A:
undetectable		 3ravA-2lm0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		4 / 8 ASP A1546
SER A1549
HIS A1535
GLU A1498
 None
 0.99A 3sg9B-2lm0A:
undetectable		 3sg9B-2lm0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens) 		4 / 6 VAL A 763
HIS A1511
LEU A1514
LEU A1558
 None
 1.21A 5hrqB-2lm0A:
undetectable
5hrqI-2lm0A:
undetectable
5hrqJ-2lm0A:
undetectable		 5hrqB-2lm0A:
14.55
5hrqI-2lm0A:
14.46
5hrqJ-2lm0A:
14.55