SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4001_1 (SERUM ALBUMIN)	2lmc	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	4 / 5	ARG B 77 ALA B 28 ASP B 52 GLY B 32	None	1.14A	1e7cA-2lmcB: undetectable	1e7cA-2lmcB: 7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETB_2_T442129_1 (TRANSTHYRETIN)	2lmc	BACTERIAL RNA POLYMERASE INHIBITOR (Escherichia virus T7)	4 / 6	GLU A 61 THR A 55 ALA A 53 LEU A 29	None	1.20A	1etb2-2lmcA: undetectable	1etb2-2lmcA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VQ5_B_LDPB1197_1 (S-NORCOCLAURINE SYNTHASE)	2lmc	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	4 / 7	LEU B 46 TYR B 57 GLU B 59 PRO B 24	None	0.88A	2vq5B-2lmcB: undetectable	2vq5B-2lmcB: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_A_HISA402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	2lmc	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 10	GLY B 72 ASN B 68 VAL B 75 ALA B 28 LEU B 46	None	1.05A	6czmA-2lmcB: undetectable 6czmC-2lmcB: undetectable	6czmA-2lmcB: 12.25 6czmC-2lmcB: 12.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7C_A_HLTA4001_1","SERUM ALBUMIN","2lmc","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",4,"ARG B  77;ALA B  28;ASP B  52;GLY B  32","None","1.14A","1e7cA-2lmcB:undetectable","1e7cA-2lmcB:7.87"],["1ETB_2_T442129_1","TRANSTHYRETIN","2lmc","BACTERIAL RNA POLYMERASE INHIBITOR","Escherichia virus T7",4,"GLU A  61;THR A  55;ALA A  53;LEU A  29","None","1.20A","1etb2-2lmcA:undetectable","1etb2-2lmcA:22.22"],["2VQ5_B_LDPB1197_1","S-NORCOCLAURINE SYNTHASE","2lmc","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",4,"LEU B  46;TYR B  57;GLU B  59;PRO B  24","None","0.88A","2vq5B-2lmcB:undetectable","2vq5B-2lmcB:19.25"],["6CZM_A_HISA402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","2lmc","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"GLY B  72;ASN B  68;VAL B  75;ALA B  28;LEU B  46","None","1.05A","6czmA-2lmcB:undetectable;6czmC-2lmcB:undetectable","6czmA-2lmcB:12.25;6czmC-2lmcB:12.25"]]