SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2lmd PROSPERO HOMEOBOX
PROTEIN 1
(Homo
sapiens) 		5 / 11 LYS A  24
ALA A  25
LEU A  40
SER A  36
THR A  32
 None
 1.20A 1tz8A-2lmdA:
undetectable
1tz8B-2lmdA:
undetectable		 1tz8A-2lmdA:
21.86
1tz8B-2lmdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2lmd PROSPERO HOMEOBOX
PROTEIN 1
(Homo
sapiens) 		4 / 6 TYR A  75
TYR A  68
GLN A 123
ILE A  92
 None
 1.14A 2pgzD-2lmdA:
undetectable
2pgzE-2lmdA:
undetectable		 2pgzD-2lmdA:
21.24
2pgzE-2lmdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2lmd PROSPERO HOMEOBOX
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  40
SER A  36
THR A  32
VAL A 158
 None
 1.04A 3d2tB-2lmdA:
undetectable		 3d2tB-2lmdA:
21.86