SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2loz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 4 PRO A1311
LEU A1281
ILE A1365
ARG A1353
 None
 1.14A 3w1wA-2lozA:
undetectable		 3w1wA-2lozA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A1282
ARG A1353
PRO A1350
ILE A1365
 None
 1.14A 5jhdE-2lozA:
undetectable
5jhdG-2lozA:
undetectable		 5jhdE-2lozA:
19.50
5jhdG-2lozA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.16A 5n0rA-2lozA:
undetectable		 5n0rA-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.17A 5n0sA-2lozA:
undetectable		 5n0sA-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.13A 5n0wA-2lozA:
undetectable		 5n0wA-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 5 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.11A 5n0wB-2lozA:
undetectable		 5n0wB-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.13A 5n0xA-2lozA:
undetectable		 5n0xA-2lozA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens) 		4 / 5 SER A1299
ALA A1298
GLN A1293
THR A1286
 None
 1.11A 5n4iA-2lozA:
undetectable		 5n4iA-2lozA:
16.59