SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 11 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 1dhiB-2lp4A:
undetectable		 1dhiB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.02A 1dhjB-2lp4A:
undetectable		 1dhjB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 1draA-2lp4A:
undetectable		 1draA-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.00A 1draB-2lp4A:
undetectable		 1draB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 1drbB-2lp4A:
undetectable		 1drbB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.07A 1ra3A-2lp4A:
undetectable		 1ra3A-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.97A 1rb2A-2lp4A:
undetectable		 1rb2A-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.03A 1rb2B-2lp4A:
undetectable		 1rb2B-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.99A 1rd7A-2lp4A:
undetectable		 1rd7A-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.04A 2drcA-2lp4A:
undetectable		 2drcA-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 2drcB-2lp4A:
undetectable		 2drcB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		3 / 3 ASN A  89
ILE A 119
MET A  69
 None
 0.83A 2h42C-2lp4A:
undetectable		 2h42C-2lp4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		4 / 6 LEU A 164
LEU A 195
ILE A 162
ARG A 161
 None
 0.99A 2rlfC-2lp4A:
undetectable
2rlfD-2lp4A:
undetectable		 2rlfC-2lp4A:
16.67
2rlfD-2lp4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.00A 3drcB-2lp4A:
undetectable		 3drcB-2lp4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 GLN A  99
LEU A 102
ILE A  50
GLY A  53
ALA A  54
 None
 1.06A 3kk6A-2lp4A:
undetectable		 3kk6A-2lp4A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 4dfrB-2lp4A:
undetectable		 4dfrB-2lp4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.95A 4ej1A-2lp4A:
undetectable		 4ej1A-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.98A 4fhbA-2lp4A:
undetectable		 4fhbA-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.95A 4i13A-2lp4A:
undetectable		 4i13A-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 0.98A 4p3rA-2lp4A:
undetectable		 4p3rA-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 11 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.02A 4p66A-2lp4A:
undetectable		 4p66A-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		5 / 12 ILE A 221
ALA A 210
LEU A 182
LEU A 175
ILE A 216
 None
 1.01A 4x5gB-2lp4A:
undetectable		 4x5gB-2lp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2lp4 CHEMOTAXIS PROTEIN
CHEA
(Escherichia
coli) 		4 / 7 GLU A 117
ILE A  61
LEU A  20
ILE A  97
 None
 0.80A 4xumA-2lp4A:
undetectable		 4xumA-2lp4A:
23.91