SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2lpm TWO-COMPONENT
RESPONSE REGULATOR
(Sinorhizobium
meliloti) 		3 / 3 ASP A  94
LEU A  75
LEU A  93
 None
 0.77A 1np1B-2lpmA:
undetectable		 1np1B-2lpmA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2lpm TWO-COMPONENT
RESPONSE REGULATOR
(Sinorhizobium
meliloti) 		4 / 6 TYR A  69
ILE A  20
GLU A  15
PHE A  84
 None
 1.26A 1oniA-2lpmA:
undetectable
1oniC-2lpmA:
undetectable		 1oniA-2lpmA:
23.61
1oniC-2lpmA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2lpm TWO-COMPONENT
RESPONSE REGULATOR
(Sinorhizobium
meliloti) 		4 / 6 ALA A  72
PHE A  84
ILE A  58
VAL A  14
 None
 0.86A 2cizA-2lpmA:
undetectable		 2cizA-2lpmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2lpm TWO-COMPONENT
RESPONSE REGULATOR
(Sinorhizobium
meliloti) 		5 / 12 ILE A  48
GLN A  53
VAL A  14
ILE A  58
LEU A  75
 None
 0.89A 3oapA-2lpmA:
undetectable		 3oapA-2lpmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2lpm TWO-COMPONENT
RESPONSE REGULATOR
(Sinorhizobium
meliloti) 		4 / 8 ILE A  58
ALA A  72
VAL A  71
ASP A  94
 None
 1.01A 6hu9a-2lpmA:
undetectable
6hu9e-2lpmA:
undetectable		 6hu9a-2lpmA:
14.11
6hu9e-2lpmA:
20.59