SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  28
SER A  59
ASN A  55
 None
 0.77A 1bx4A-2lqnA:
undetectable		 1bx4A-2lqnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 ARG A  57
VAL A 170
SER A 162
ILE A 152
 None
 0.86A 1igxA-2lqnA:
undetectable		 1igxA-2lqnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 GLY A 136
PRO A 174
PHE A 144
ASN A 165
 None
 0.98A 1oniG-2lqnA:
undetectable
1oniI-2lqnA:
undetectable		 1oniG-2lqnA:
17.32
1oniI-2lqnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 THR A 289
VAL A 266
GLY A 277
ILE A 263
 None
 0.79A 2a1mB-2lqnA:
undetectable		 2a1mB-2lqnA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 PRO A 103
ARG A 104
GLY A  17
PRO A  18
 None
 1.18A 3ucbB-2lqnA:
undetectable		 3ucbB-2lqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.04A 3wg7P-2lqnA:
undetectable
3wg7W-2lqnA:
undetectable		 3wg7P-2lqnA:
19.49
3wg7W-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  13
ASP A   7
PHE A   6
LEU A  84
VAL A  38
 None
 1.36A 4kyaB-2lqnA:
undetectable		 4kyaB-2lqnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  13
ASP A   7
PHE A   6
LEU A  84
VAL A  38
 None
 1.36A 4kyaD-2lqnA:
undetectable		 4kyaD-2lqnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  13
ASP A   7
PHE A   6
LEU A  84
VAL A  38
 None
 1.36A 4kyaF-2lqnA:
undetectable		 4kyaF-2lqnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  13
ASP A   7
PHE A   6
LEU A  84
VAL A  38
 None
 1.35A 4kyaH-2lqnA:
undetectable		 4kyaH-2lqnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  98
VAL A  58
SER A  59
HIS A  60
 None
 0.98A 4qknA-2lqnA:
undetectable		 4qknA-2lqnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.09A 5iy5P-2lqnA:
undetectable
5iy5W-2lqnA:
undetectable		 5iy5P-2lqnA:
19.29
5iy5W-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.14A 5w97C-2lqnA:
undetectable
5w97J-2lqnA:
undetectable		 5w97C-2lqnA:
19.49
5w97J-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.14A 5x1fC-2lqnA:
undetectable
5x1fJ-2lqnA:
undetectable		 5x1fC-2lqnA:
19.49
5x1fJ-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.11A 5xdxC-2lqnA:
undetectable
5xdxJ-2lqnA:
undetectable		 5xdxC-2lqnA:
19.23
5xdxJ-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.09A 5xdxP-2lqnA:
undetectable
5xdxW-2lqnA:
undetectable		 5xdxP-2lqnA:
19.23
5xdxW-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2lqn CRK-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 164
ARG A  21
ARG A  57
 None
 0.90A 6bplA-2lqnA:
undetectable
6bplB-2lqnA:
undetectable		 6bplA-2lqnA:
14.19
6bplB-2lqnA:
14.19