SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		3 / 3 TRP A  88
VAL A  34
TRP A  37
 None
 1.27A 1c4dA-2lrnA:
undetectable
1c4dB-2lrnA:
undetectable		 1c4dA-2lrnA:
11.54
1c4dB-2lrnA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		5 / 11 VAL A 116
GLU A 119
LYS A  28
VAL A 101
PHE A  36
 None
 1.29A 1gx9A-2lrnA:
undetectable		 1gx9A-2lrnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		4 / 7 CYH A  41
SER A  42
PHE A  38
LEU A  93
 None
 1.06A 1qcaA-2lrnA:
undetectable		 1qcaA-2lrnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		4 / 7 ASP A  71
TRP A  37
SER A  86
THR A  48
 None
 1.20A 3dzgB-2lrnA:
undetectable		 3dzgB-2lrnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		4 / 6 GLY A 120
VAL A 116
PRO A 118
TYR A  31
 None
 0.85A 4dxuA-2lrnA:
undetectable		 4dxuA-2lrnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		3 / 3 ARG A  45
LYS A  79
GLU A  83
 None
 0.82A 5d0yA-2lrnA:
undetectable		 5d0yA-2lrnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		3 / 3 ARG A 128
PRO A 111
TYR A  50
 None
 0.89A 5tzoB-2lrnA:
undetectable		 5tzoB-2lrnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		4 / 7 SER A   7
ILE A 122
LEU A   3
PRO A  10
 None
 0.98A 5u4sA-2lrnA:
undetectable		 5u4sA-2lrnA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN
(Bacteroides
sp.
4_3_47FAA) 		4 / 8 SER A   7
ILE A 122
LEU A   3
PRO A  10
 None
 0.97A 5u4sB-2lrnA:
2.0		 5u4sB-2lrnA:
18.78