SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_B_ESTB354_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	2lru	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Rattus norvegicus)	4 / 8	VAL A 485 LEU A 504 MET A 540 VAL A 536	None	0.99A	1fduB-2lruA: undetectable	1fduB-2lruA: 15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_A_SAMA405_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	2lru	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Rattus norvegicus)	4 / 8	ALA A 557 ASP A 518 ILE A 506 ASP A 550	None	0.86A	4kttB-2lruA: undetectable	4kttB-2lruA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_C_SAMC404_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	2lru	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Rattus norvegicus)	4 / 8	ALA A 557 ASP A 518 ILE A 506 ASP A 550	None	0.91A	4kttD-2lruA: undetectable	4kttD-2lruA: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBN_B_SAMB401_0 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	2lru	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Rattus norvegicus)	4 / 7	ALA A 557 ASP A 518 ILE A 506 ASP A 550	None	0.85A	6fbnA-2lruA: undetectable	6fbnA-2lruA: 14.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FDU_B_ESTB354_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","2lru","SERINE\/THREONINE-PROTEIN KINASE WNK1","Rattus norvegicus",4,"VAL A 485;LEU A 504;MET A 540;VAL A 536","None","0.99A","1fduB-2lruA:undetectable","1fduB-2lruA:15.36"],["4KTT_A_SAMA405_1","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","2lru","SERINE\/THREONINE-PROTEIN KINASE WNK1","Rattus norvegicus",4,"ALA A 557;ASP A 518;ILE A 506;ASP A 550","None","0.86A","4kttB-2lruA:undetectable","4kttB-2lruA:14.44"],["4KTT_C_SAMC404_1","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","2lru","SERINE\/THREONINE-PROTEIN KINASE WNK1","Rattus norvegicus",4,"ALA A 557;ASP A 518;ILE A 506;ASP A 550","None","0.91A","4kttD-2lruA:undetectable","4kttD-2lruA:14.44"],["6FBN_B_SAMB401_0","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","2lru","SERINE\/THREONINE-PROTEIN KINASE WNK1","Rattus norvegicus",4,"ALA A 557;ASP A 518;ILE A 506;ASP A 550","None","0.85A","6fbnA-2lruA:undetectable","6fbnA-2lruA:14.44"]]