SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ls0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2ls0 ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		3 / 3 ASN 1  53
TRP 1 115
GLN 1  37
 None
 1.15A 1xoqA-2ls01:
undetectable		 1xoqA-2ls01:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2ls0 ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		5 / 12 ASP 1  59
GLY 1 111
GLY 1 112
PHE 1 108
ASP 1  52
 None
 0.85A 4ubeA-2ls01:
undetectable		 4ubeA-2ls01:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ls0 ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		5 / 11 PRO 1  85
LEU 1  21
VAL 1  63
GLY 1  67
TYR 1 126
 None
 1.14A 5hbmA-2ls01:
undetectable		 5hbmA-2ls01:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 2ls0 ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		5 / 11 SER 1  98
PHE 1  48
ASP 1  52
VAL 1 106
LEU 1 124
 None
 1.49A 5jdcA-2ls01:
undetectable
5jdcD-2ls01:
undetectable		 5jdcA-2ls01:
21.43
5jdcD-2ls01:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2ls0 ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 7 TYR 1  24
VAL 1  38
VAL 1  60
ALA 1  57
 None
 0.77A 5osrA-2ls01:
undetectable		 5osrA-2ls01:
15.74