SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ls8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_A_NOVA400_2 (DNA GYRASE SUBUNIT B)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	3 / 3	ASN A 114 PHE A 61 VAL A 116	None	0.81A	1kijA-2ls8A: undetectable	1kijA-2ls8A: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U1J_A_C2FA773_0 (5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	4 / 8	ARG A 56 ASN A 114 SER A 59 ARG A 57	None	1.19A	1u1jA-2ls8A: undetectable	1u1jA-2ls8A: 10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_A_DEXA247_2 (GLUCOCORTICOID RECEPTOR 2)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	3 / 3	MET A 34 MET A 1 PHE A 16	None	0.96A	3gn8A-2ls8A: undetectable	3gn8A-2ls8A: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LRH_A_FOLA301_1 (FOLATE RECEPTOR ALPHA)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	3 / 3	ASP A 20 TRP A 111 SER A 27	None	1.07A	4lrhA-2ls8A: undetectable	4lrhA-2ls8A: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G08_A_Z80A1187_1 (FREQUENIN 2)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	4 / 6	ILE A 50 TYR A 15 PHE A 10 THR A 79	None	1.30A	5g08A-2ls8A: undetectable	5g08A-2ls8A: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKQ_A_JMSA602_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2ls8	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D (Homo sapiens)	3 / 3	VAL A 116 SER A 59 MET A 39	None	0.86A	5ikqA-2ls8A: undetectable	5ikqA-2ls8A: 12.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIJ_A_NOVA400_2","DNA GYRASE SUBUNIT B","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",3,"ASN A 114;PHE A  61;VAL A 116","None","0.81A","1kijA-2ls8A:undetectable","1kijA-2ls8A:16.88"],["1U1J_A_C2FA773_0","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",4,"ARG A  56;ASN A 114;SER A  59;ARG A  57","None","1.19A","1u1jA-2ls8A:undetectable","1u1jA-2ls8A:10.20"],["3GN8_A_DEXA247_2","GLUCOCORTICOID RECEPTOR 2","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",3,"MET A  34;MET A   1;PHE A  16","None","0.96A","3gn8A-2ls8A:undetectable","3gn8A-2ls8A:18.58"],["4LRH_A_FOLA301_1","FOLATE RECEPTOR ALPHA","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",3,"ASP A  20;TRP A 111;SER A  27","None","1.07A","4lrhA-2ls8A:undetectable","4lrhA-2ls8A:20.35"],["5G08_A_Z80A1187_1","FREQUENIN 2","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",4,"ILE A  50;TYR A  15;PHE A  10;THR A  79","None","1.30A","5g08A-2ls8A:undetectable","5g08A-2ls8A:21.24"],["5IKQ_A_JMSA602_2","PROSTAGLANDIN G\/H SYNTHASE 2","2ls8","C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D","Homo sapiens",3,"VAL A 116;SER A  59;MET A  39","None","0.86A","5ikqA-2ls8A:undetectable","5ikqA-2ls8A:12.27"]]