SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		3 / 3 LEU A  50
SER A  45
ASN A  43
 None
 0.81A 1bx4A-2lshA:
undetectable		 1bx4A-2lshA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 0.99A 1rg7A-2lshA:
undetectable		 1rg7A-2lshA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 1.02A 2drcA-2lshA:
undetectable		 2drcA-2lshA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
ILE A  73
PHE A  18
 None
 1.21A 2qk8A-2lshA:
undetectable		 2qk8A-2lshA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 0.98A 3ia4D-2lshA:
undetectable		 3ia4D-2lshA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 1.03A 4dfrA-2lshA:
undetectable		 4dfrA-2lshA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 1.00A 4qi9A-2lshA:
undetectable		 4qi9A-2lshA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 1.02A 4qi9B-2lshA:
undetectable		 4qi9B-2lshA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 11 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 1.06A 4qleB-2lshA:
undetectable		 4qleB-2lshA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		5 / 12 ALA A  96
LEU A  81
LYS A  92
SER A  71
ILE A  73
 None
 0.94A 5hi6A-2lshA:
undetectable		 5hi6A-2lshA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2lsh SPORE-WALL FUNGAL
HYDROPHOBIN DEWA
(Aspergillus
nidulans) 		4 / 7 GLY A  52
GLY A  49
SER A  65
ALA A  68
 None
 0.73A 5o96C-2lshA:
undetectable		 5o96C-2lshA:
17.14