SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 8 LEU A  70
VAL A  83
LEU A  85
ALA A  11
 None
 0.93A 1fiqC-2lstA:
undetectable		 1fiqC-2lstA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 8 LEU A  70
VAL A  83
LEU A  85
ALA A  58
 None
 0.90A 1fiqC-2lstA:
undetectable		 1fiqC-2lstA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 8 LEU A  70
VAL A  83
LEU A  85
ALA A  58
 None
 0.93A 3uniB-2lstA:
2.2		 3uniB-2lstA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 7 ARG A 102
ARG A  97
GLY A  96
GLU A  94
 None
 0.98A 5btaA-2lstA:
undetectable
5btaC-2lstA:
undetectable
5btaD-2lstA:
undetectable		 5btaA-2lstA:
13.69
5btaC-2lstA:
13.69
5btaD-2lstA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 6 ARG A  97
GLY A  96
GLU A  94
ARG A 102
 None
 1.01A 5btaA-2lstA:
undetectable
5btaB-2lstA:
undetectable
5btaC-2lstA:
undetectable		 5btaA-2lstA:
13.69
5btaB-2lstA:
17.39
5btaC-2lstA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 6 ARG A 102
ARG A  97
GLY A  96
GLU A  94
 None
 1.04A 5btcA-2lstA:
undetectable
5btcC-2lstA:
undetectable
5btcD-2lstA:
undetectable		 5btcA-2lstA:
13.69
5btcC-2lstA:
13.69
5btcD-2lstA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 6 ARG A  97
GLY A  96
GLU A  94
ARG A 102
 None
 1.00A 5btcA-2lstA:
undetectable
5btcB-2lstA:
undetectable
5btcC-2lstA:
undetectable		 5btcA-2lstA:
13.69
5btcB-2lstA:
17.39
5btcC-2lstA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2lst THIOREDOXIN
(Thermus
thermophilus) 		4 / 5 ARG A  97
GLY A  96
GLU A  94
ARG A 102
 None
 0.99A 5cdqR-2lstA:
undetectable
5cdqS-2lstA:
undetectable
5cdqT-2lstA:
undetectable		 5cdqR-2lstA:
13.32
5cdqS-2lstA:
16.58
5cdqT-2lstA:
13.32