SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KF6_B_ACTB704_0 (FUMARATE REDUCTASE FLAVOPROTEIN FUMARATE REDUCTASE IRON-SULFUR PROTEIN)	2lta	DE NOVO DESIGNED PROTEIN (synthetic construct)	3 / 3	ARG A 82 GLY A 101 ASP A 96	None	0.58A	1kf6A-2ltaA: undetectable 1kf6B-2ltaA: undetectable	1kf6A-2ltaA: 12.34 1kf6B-2ltaA: 16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_A_5FWA1001_1 (SUPEROXIDE DISMUTASE [CU-ZN])	2lta	DE NOVO DESIGNED PROTEIN (synthetic construct)	3 / 3	ASP A 38 LYS A 37 ASP A 36	None	0.79A	4a7tA-2ltaA: undetectable	4a7tA-2ltaA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	2lta	DE NOVO DESIGNED PROTEIN (synthetic construct)	4 / 7	TYR A 31 VAL A 7 ILE A 9 GLU A 75	None	1.13A	4a97E-2ltaA: undetectable	4a97E-2ltaA: 17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIX_A_NIMA201_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	2lta	DE NOVO DESIGNED PROTEIN (synthetic construct)	4 / 4	LEU A 49 ALA A 20 ILE A 8 LYS A 45	None	1.26A	4eixA-2ltaA: undetectable	4eixA-2ltaA: 18.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KF6_B_ACTB704_0","FUMARATE REDUCTASE FLAVOPROTEIN;FUMARATE REDUCTASE IRON-SULFUR PROTEIN","2lta","DE NOVO DESIGNED PROTEIN","synthetic construct",3,"ARG A  82;GLY A 101;ASP A  96","None","0.58A","1kf6A-2ltaA:undetectable;1kf6B-2ltaA:undetectable","1kf6A-2ltaA:12.34;1kf6B-2ltaA:16.18"],["4A7T_A_5FWA1001_1","SUPEROXIDE DISMUTASE [CU-ZN]","2lta","DE NOVO DESIGNED PROTEIN","synthetic construct",3,"ASP A  38;LYS A  37;ASP A  36","None","0.79A","4a7tA-2ltaA:undetectable","4a7tA-2ltaA:21.15"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","2lta","DE NOVO DESIGNED PROTEIN","synthetic construct",4,"TYR A  31;VAL A   7;ILE A   9;GLU A  75","None","1.13A","4a97E-2ltaA:undetectable","4a97E-2ltaA:17.09"],["4EIX_A_NIMA201_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","2lta","DE NOVO DESIGNED PROTEIN","synthetic construct",4,"LEU A  49;ALA A  20;ILE A   8;LYS A  45","None","1.26A","4eixA-2ltaA:undetectable","4eixA-2ltaA:18.90"]]