SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ltl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 110
ILE A  17
ILE A  19
ASP A 103
 None
 0.93A 1upfB-2ltlA:
undetectable		 1upfB-2ltlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  63
LEU A 105
ILE A  58
LEU A  30
VAL A  74
 None
 1.23A 2hrcB-2ltlA:
undetectable		 2hrcB-2ltlA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  82
THR A  24
PRO A  25
 None
 0.65A 2pynB-2ltlA:
undetectable		 2pynB-2ltlA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  82
THR A  24
PRO A  25
 None
 0.67A 2qakB-2ltlA:
undetectable		 2qakB-2ltlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  32
ILE A 102
ASP A  36
 None
 0.35A 5cswA-2ltlA:
undetectable		 5cswA-2ltlA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  32
ILE A 102
ASP A  36
 None
 0.42A 5cswB-2ltlA:
undetectable		 5cswB-2ltlA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  74
GLU A  75
ILE A  86
 None
 0.49A 6f7lB-2ltlA:
undetectable		 6f7lB-2ltlA:
14.75