SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ltm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A  80
GLY A  60
LEU A  85
GLU A  59
 None
 1.12A 3tgvB-2ltmA:
undetectable		 3tgvB-2ltmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A  93
LEU A  33
LEU A  51
PRO A  28
ILE A  27
 None
 1.05A 3vrmA-2ltmA:
undetectable		 3vrmA-2ltmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN A  22
PRO A  21
TRP A  82
PHE A  26
 None
 1.36A 4v32C-2ltmA:
undetectable		 4v32C-2ltmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A  71
LEU A  51
PHE A  66
ARG A  36
GLY A  67
 None
 1.24A 5k7uA-2ltmA:
undetectable		 5k7uA-2ltmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 VAL A  64
ILE A  89
LEU A  55
ILE A  93
ILE A  13
 None
 1.21A 5numA-2ltmA:
undetectable		 5numA-2ltmA:
22.22