SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ltp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFS_A_J01A500_1 (ORF12)	2ltp	NUCLEAR RECEPTOR COREPRESSOR 2 (Homo sapiens)	5 / 8	TRP A 20 VAL A 32 LEU A 48 ARG A 18 GLY A 17	None	1.41A	2xfsA-2ltpA: undetectable	2xfsA-2ltpA: 9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XH9_B_J01B1436_1 (ORF12)	2ltp	NUCLEAR RECEPTOR COREPRESSOR 2 (Homo sapiens)	5 / 9	TRP A 20 VAL A 32 LEU A 48 ARG A 18 GLY A 17	None	1.49A	2xh9B-2ltpA: undetectable	2xh9B-2ltpA: 9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA502_0 (RNA POLYMERASE 3D-POL)	2ltp	NUCLEAR RECEPTOR COREPRESSOR 2 (Homo sapiens)	3 / 3	ARG A 67 LYS A 68 LYS A 69	None	1.18A	4k50A-2ltpA: undetectable	4k50A-2ltpA: 10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	2ltp	NUCLEAR RECEPTOR COREPRESSOR 2 (Homo sapiens)	3 / 3	ARG A 67 LYS A 68 LYS A 69	None	1.21A	4k50E-2ltpA: undetectable	4k50E-2ltpA: 10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI506_0 (RNA POLYMERASE 3D-POL)	2ltp	NUCLEAR RECEPTOR COREPRESSOR 2 (Homo sapiens)	3 / 3	ARG A 67 LYS A 68 LYS A 69	None	1.23A	4k50I-2ltpA: undetectable	4k50I-2ltpA: 10.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XFS_A_J01A500_1","ORF12","2ltp","NUCLEAR RECEPTOR COREPRESSOR 2","Homo sapiens",5,"TRP A  20;VAL A  32;LEU A  48;ARG A  18;GLY A  17","None","1.41A","2xfsA-2ltpA:undetectable","2xfsA-2ltpA:9.83"],["2XH9_B_J01B1436_1","ORF12","2ltp","NUCLEAR RECEPTOR COREPRESSOR 2","Homo sapiens",5,"TRP A  20;VAL A  32;LEU A  48;ARG A  18;GLY A  17","None","1.49A","2xh9B-2ltpA:undetectable","2xh9B-2ltpA:9.83"],["4K50_A_ACTA502_0","RNA POLYMERASE 3D-POL","2ltp","NUCLEAR RECEPTOR COREPRESSOR 2","Homo sapiens",3,"ARG A  67;LYS A  68;LYS A  69","None","1.18A","4k50A-2ltpA:undetectable","4k50A-2ltpA:10.65"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","2ltp","NUCLEAR RECEPTOR COREPRESSOR 2","Homo sapiens",3,"ARG A  67;LYS A  68;LYS A  69","None","1.21A","4k50E-2ltpA:undetectable","4k50E-2ltpA:10.65"],["4K50_I_ACTI506_0","RNA POLYMERASE 3D-POL","2ltp","NUCLEAR RECEPTOR COREPRESSOR 2","Homo sapiens",3,"ARG A  67;LYS A  68;LYS A  69","None","1.23A","4k50I-2ltpA:undetectable","4k50I-2ltpA:10.65"]]